Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

BACKGROUND: Changes in blood-brain barrier (BBB) functionality have been implicated in Parkinson's disease. This study aimed to investigate BBB transport of L-DOPA transport in conjunction with its intra-brain conversion, in both control and diseased cerebral hemispheres in the unilateral rat r...

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Detalles Bibliográficos
Autores principales: Ravenstijn, Paulien GM, Drenth, Henk-Jan, O'Neill, Michael J, Danhof, Meindert, de Lange, Elizabeth CM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298802/
https://www.ncbi.nlm.nih.gov/pubmed/22316420
http://dx.doi.org/10.1186/2045-8118-9-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298802/
https://www.ncbi.nlm.nih.gov/pubmed/22316420
http://dx.doi.org/10.1186/2045-8118-9-4

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