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First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results

OBJECTIVES: Malaria infection of the placenta during pregnancy was found to be associated with infant susceptibility to malaria. Other factors such as the intensity of malaria transmission and the nutritional status of the child might also play a role, which has not been adequately taken into accoun...

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Autores principales: Le Port, Agnès, Cottrell, Gilles, Martin-Prevel, Yves, Migot-Nabias, Florence, Cot, Michel, Garcia, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298838/
https://www.ncbi.nlm.nih.gov/pubmed/22403339
http://dx.doi.org/10.1136/bmjopen-2011-000342
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author Le Port, Agnès
Cottrell, Gilles
Martin-Prevel, Yves
Migot-Nabias, Florence
Cot, Michel
Garcia, André
author_facet Le Port, Agnès
Cottrell, Gilles
Martin-Prevel, Yves
Migot-Nabias, Florence
Cot, Michel
Garcia, André
author_sort Le Port, Agnès
collection PubMed
description OBJECTIVES: Malaria infection of the placenta during pregnancy was found to be associated with infant susceptibility to malaria. Other factors such as the intensity of malaria transmission and the nutritional status of the child might also play a role, which has not been adequately taken into account in previous studies. The aim of this study was to assess precisely the parts played by environmental, nutritional and biological determinants in first malaria infections, with a special interest in the role of placental infection. The objective of this paper is not to present final results but to outline the rationale of the study, to describe the methods used and to report baseline data. DESIGN: A cohort of infants followed with a parasitological (symptomatic and asymptomatic parasitaemia) and nutritional follow-up from birth to 18 months. Ecological, entomological and behavioural data were collected along the duration of the study. SETTING: A rural area in Benin with two seasonal peaks in malaria transmission. PARTICIPANTS: 656 infants of women willing to participate in the study, giving birth in one of the three maternity clinics and living in one of the nine villages of the study area. PRIMARY OUTCOME MEASURES: The time and frequency of first malaria parasitaemias in infants, according to Plasmodium falciparum infection of the placenta. RESULTS: 11% of mothers had a malaria-infected placenta at delivery. Mosquito catches made every 6 weeks in the area showed an average annual P falciparum entomological inoculation rate of 15.5, with important time and space variations depending on villages. Similarly, the distribution of rainfalls, maximal during the two rainy seasons, was heterogeneous over the area. CONCLUSIONS: Considering the multidisciplinary approach of all factors potentially influencing the malaria status of newborn babies, this study should bring evidence on the implication of placental malaria in the occurrence of first malaria infections in infants.
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spelling pubmed-32988382012-03-12 First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results Le Port, Agnès Cottrell, Gilles Martin-Prevel, Yves Migot-Nabias, Florence Cot, Michel Garcia, André BMJ Open Infectious Diseases OBJECTIVES: Malaria infection of the placenta during pregnancy was found to be associated with infant susceptibility to malaria. Other factors such as the intensity of malaria transmission and the nutritional status of the child might also play a role, which has not been adequately taken into account in previous studies. The aim of this study was to assess precisely the parts played by environmental, nutritional and biological determinants in first malaria infections, with a special interest in the role of placental infection. The objective of this paper is not to present final results but to outline the rationale of the study, to describe the methods used and to report baseline data. DESIGN: A cohort of infants followed with a parasitological (symptomatic and asymptomatic parasitaemia) and nutritional follow-up from birth to 18 months. Ecological, entomological and behavioural data were collected along the duration of the study. SETTING: A rural area in Benin with two seasonal peaks in malaria transmission. PARTICIPANTS: 656 infants of women willing to participate in the study, giving birth in one of the three maternity clinics and living in one of the nine villages of the study area. PRIMARY OUTCOME MEASURES: The time and frequency of first malaria parasitaemias in infants, according to Plasmodium falciparum infection of the placenta. RESULTS: 11% of mothers had a malaria-infected placenta at delivery. Mosquito catches made every 6 weeks in the area showed an average annual P falciparum entomological inoculation rate of 15.5, with important time and space variations depending on villages. Similarly, the distribution of rainfalls, maximal during the two rainy seasons, was heterogeneous over the area. CONCLUSIONS: Considering the multidisciplinary approach of all factors potentially influencing the malaria status of newborn babies, this study should bring evidence on the implication of placental malaria in the occurrence of first malaria infections in infants. BMJ Group 2012-03-08 /pmc/articles/PMC3298838/ /pubmed/22403339 http://dx.doi.org/10.1136/bmjopen-2011-000342 Text en © 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Infectious Diseases
Le Port, Agnès
Cottrell, Gilles
Martin-Prevel, Yves
Migot-Nabias, Florence
Cot, Michel
Garcia, André
First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results
title First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results
title_full First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results
title_fullStr First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results
title_full_unstemmed First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results
title_short First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. Description of the study site, population methods and preliminary results
title_sort first malaria infections in a cohort of infants in benin: biological, environmental and genetic determinants. description of the study site, population methods and preliminary results
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298838/
https://www.ncbi.nlm.nih.gov/pubmed/22403339
http://dx.doi.org/10.1136/bmjopen-2011-000342
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