Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia

Tauopathies including tau-associated Frontotemporal dementia (FTD) and Alzheimer’s disease are characterized pathologically by the formation of tau-containing neurofibrillary aggregates and neuronal loss, which contribute to cognitive decline. There are currently no effective treatments to prevent o...

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Detalles Bibliográficos
Autores principales: Spires-Jones, Tara L., Fox, Leora M., Rozkalne, Anete, Pitstick, Rose, Carlson, George A., Kazantsev, Aleksey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298895/
https://www.ncbi.nlm.nih.gov/pubmed/22416232
http://dx.doi.org/10.3389/fphar.2012.00042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298895/
https://www.ncbi.nlm.nih.gov/pubmed/22416232
http://dx.doi.org/10.3389/fphar.2012.00042

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