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Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia

Tauopathies including tau-associated Frontotemporal dementia (FTD) and Alzheimer’s disease are characterized pathologically by the formation of tau-containing neurofibrillary aggregates and neuronal loss, which contribute to cognitive decline. There are currently no effective treatments to prevent o...

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Detalles Bibliográficos
Autores principales:	Spires-Jones, Tara L., Fox, Leora M., Rozkalne, Anete, Pitstick, Rose, Carlson, George A., Kazantsev, Aleksey G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298895/ https://www.ncbi.nlm.nih.gov/pubmed/22416232 http://dx.doi.org/10.3389/fphar.2012.00042

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