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Prevalence and Immunization Status of Hepatitis B Virus in the HIV Cohort in Fife, Scotland

BACKGROUND: Routes of transmission of hepatitis B virus (HBV)/HIV infections are similar and there is a significant rate of co-infection in patients. A study was recently carried out in NHS Fife, Scotland from February 2007 - February 2008 to estimate the prevalence of HBV/HIV co-infection, occult H...

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Autores principales: Hakeem, Lukman, Thomson, Grace, McCleary, Eleanor, Bhattacharyya, Diptendu, Banerjee, Indranil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299173/
https://www.ncbi.nlm.nih.gov/pubmed/22457699
http://dx.doi.org/10.4021/jocmr2009.12.1282
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author Hakeem, Lukman
Thomson, Grace
McCleary, Eleanor
Bhattacharyya, Diptendu
Banerjee, Indranil
author_facet Hakeem, Lukman
Thomson, Grace
McCleary, Eleanor
Bhattacharyya, Diptendu
Banerjee, Indranil
author_sort Hakeem, Lukman
collection PubMed
description BACKGROUND: Routes of transmission of hepatitis B virus (HBV)/HIV infections are similar and there is a significant rate of co-infection in patients. A study was recently carried out in NHS Fife, Scotland from February 2007 - February 2008 to estimate the prevalence of HBV/HIV co-infection, occult HBV infection and immunisation status against HBV in a cohort of patients with HIV attending the departments of infectious diseases and genitourinary medicine. METHODS: Case notes were reviewed retrospectively (n = 70). Details on patient demographics, risk category, nadir/current CD4 count, HIV viral load and vaccination history were analysed. HBV markers (HBsAg/anti-HBs/anti-HBc/HBV DNA) and alanine transaminase (ALT) levels were tested prospectively if these tests had not been carried out in the previous 12 months. RESULTS AND CONCLUSION: Prevalence of HBV/HIV co-infection was 5.6% of which 2.8% of patients had occult infection and 22.9% had evidence of previous exposure. Although HBV is preventable by vaccination, only 24.2% of patients had been vaccinated against it. Improvements could therefore be made in the field of prevention with vaccination and monitoring the immune response in this cohort. KEYWORDS: Prevalence; Immunization status; Hepatitis B Virus; HIV
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spelling pubmed-32991732012-03-28 Prevalence and Immunization Status of Hepatitis B Virus in the HIV Cohort in Fife, Scotland Hakeem, Lukman Thomson, Grace McCleary, Eleanor Bhattacharyya, Diptendu Banerjee, Indranil J Clin Med Res Original Article BACKGROUND: Routes of transmission of hepatitis B virus (HBV)/HIV infections are similar and there is a significant rate of co-infection in patients. A study was recently carried out in NHS Fife, Scotland from February 2007 - February 2008 to estimate the prevalence of HBV/HIV co-infection, occult HBV infection and immunisation status against HBV in a cohort of patients with HIV attending the departments of infectious diseases and genitourinary medicine. METHODS: Case notes were reviewed retrospectively (n = 70). Details on patient demographics, risk category, nadir/current CD4 count, HIV viral load and vaccination history were analysed. HBV markers (HBsAg/anti-HBs/anti-HBc/HBV DNA) and alanine transaminase (ALT) levels were tested prospectively if these tests had not been carried out in the previous 12 months. RESULTS AND CONCLUSION: Prevalence of HBV/HIV co-infection was 5.6% of which 2.8% of patients had occult infection and 22.9% had evidence of previous exposure. Although HBV is preventable by vaccination, only 24.2% of patients had been vaccinated against it. Improvements could therefore be made in the field of prevention with vaccination and monitoring the immune response in this cohort. KEYWORDS: Prevalence; Immunization status; Hepatitis B Virus; HIV Elmer Press 2010-02 2010-02-08 /pmc/articles/PMC3299173/ /pubmed/22457699 http://dx.doi.org/10.4021/jocmr2009.12.1282 Text en Copyright 2010, Hakeem et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hakeem, Lukman
Thomson, Grace
McCleary, Eleanor
Bhattacharyya, Diptendu
Banerjee, Indranil
Prevalence and Immunization Status of Hepatitis B Virus in the HIV Cohort in Fife, Scotland
title Prevalence and Immunization Status of Hepatitis B Virus in the HIV Cohort in Fife, Scotland
title_full Prevalence and Immunization Status of Hepatitis B Virus in the HIV Cohort in Fife, Scotland
title_fullStr Prevalence and Immunization Status of Hepatitis B Virus in the HIV Cohort in Fife, Scotland
title_full_unstemmed Prevalence and Immunization Status of Hepatitis B Virus in the HIV Cohort in Fife, Scotland
title_short Prevalence and Immunization Status of Hepatitis B Virus in the HIV Cohort in Fife, Scotland
title_sort prevalence and immunization status of hepatitis b virus in the hiv cohort in fife, scotland
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299173/
https://www.ncbi.nlm.nih.gov/pubmed/22457699
http://dx.doi.org/10.4021/jocmr2009.12.1282
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