Degradable polyethylenimine derivate coupled to a bifunctional peptide R13 as a new gene-delivery vector

BACKGROUND: To solve the efficiency versus cytotoxicity and tumor-targeting problems of polyethylenimine (PEI) used as a nonviral gene delivery vector, a degradable PEI derivate coupled to a bifunctional peptide R13 was developed. METHODS: First, we synthesized a degradable PEI derivate by crosslink...

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Detalles Bibliográficos
Autores principales: Liu, Kehai, Wang, Xiaoyu, Fan, Wei, Zhu, Qing, Yang, Jingya, Gao, Jing, Gao, Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299202/
https://www.ncbi.nlm.nih.gov/pubmed/22412301
http://dx.doi.org/10.2147/IJN.S28819

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