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Degradable polyethylenimine derivate coupled to a bifunctional peptide R13 as a new gene-delivery vector
BACKGROUND: To solve the efficiency versus cytotoxicity and tumor-targeting problems of polyethylenimine (PEI) used as a nonviral gene delivery vector, a degradable PEI derivate coupled to a bifunctional peptide R13 was developed. METHODS: First, we synthesized a degradable PEI derivate by crosslink...
Autores principales: | Liu, Kehai, Wang, Xiaoyu, Fan, Wei, Zhu, Qing, Yang, Jingya, Gao, Jing, Gao, Shen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299202/ https://www.ncbi.nlm.nih.gov/pubmed/22412301 http://dx.doi.org/10.2147/IJN.S28819 |
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