Protection of adenovirus from neutralizing antibody by cationic PEG derivative ionically linked to adenovirus

BACKGROUND: The generation of anti-adenovirus neutralizing antibody (NAb) in humans severely restricts the utilization of recombinant adenovirus serotype 5 (Ad5) vectors in gene therapy for a wide range of clinical trials. To overcome this limitation, we ionically complexed Ad5 with a newly synthesi...

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Detalles Bibliográficos
Autores principales: Zeng, Qin, Han, Jianfeng, Zhao, Dong, Gong, Tao, Zhang, Zhirong, Sun, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299205/
https://www.ncbi.nlm.nih.gov/pubmed/22412299
http://dx.doi.org/10.2147/IJN.S27526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299205/
https://www.ncbi.nlm.nih.gov/pubmed/22412299
http://dx.doi.org/10.2147/IJN.S27526

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