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Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention

The maintenance of tunneled catheter (TC) patency is critical for the provision of adequate hemodialysis in patients who are TC-dependent. TC dysfunction results in the need for costly and inconvenient interventions, and reduced quality of life. Since the introduction of TCs in the late 1980s, hepar...

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Autores principales: Lee, Timmy, Lok, Charmaine, Vazquez, Miguel, Moist, Louise, Maya, Ivan, Mokrzycki, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299246/
https://www.ncbi.nlm.nih.gov/pubmed/22518310
http://dx.doi.org/10.1155/2012/170857
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author Lee, Timmy
Lok, Charmaine
Vazquez, Miguel
Moist, Louise
Maya, Ivan
Mokrzycki, Michele
author_facet Lee, Timmy
Lok, Charmaine
Vazquez, Miguel
Moist, Louise
Maya, Ivan
Mokrzycki, Michele
author_sort Lee, Timmy
collection PubMed
description The maintenance of tunneled catheter (TC) patency is critical for the provision of adequate hemodialysis in patients who are TC-dependent. TC dysfunction results in the need for costly and inconvenient interventions, and reduced quality of life. Since the introduction of TCs in the late 1980s, heparin catheter lock has been the standard prophylactic regimen for the prevention of TC dysfunction. More recently, alternative catheter locking agents have emerged, and in some cases have shown to be superior to heparin lock with respect to improving TC patency and reducing TC-associated infections. These include citrate, tissue plasminogen activator, and a novel agent containing sodium citrate, methylene blue, methylparaben, and propylparaben. In addition, prophylaxis using oral anticoagulants/antiplatelet agents, including warfarin, aspirin, ticlodipine, as well as the use of modified heparin-coated catheters have also been studied for the prevention of TC dysfunction with variable results. The use of oral anticoagulants and/or antiplatelet agents as primary or secondary prevention of TC dysfunction must be weighed against their potential adverse effects, and should be individualized for each patient.
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spelling pubmed-32992462012-04-19 Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention Lee, Timmy Lok, Charmaine Vazquez, Miguel Moist, Louise Maya, Ivan Mokrzycki, Michele Int J Nephrol Review Article The maintenance of tunneled catheter (TC) patency is critical for the provision of adequate hemodialysis in patients who are TC-dependent. TC dysfunction results in the need for costly and inconvenient interventions, and reduced quality of life. Since the introduction of TCs in the late 1980s, heparin catheter lock has been the standard prophylactic regimen for the prevention of TC dysfunction. More recently, alternative catheter locking agents have emerged, and in some cases have shown to be superior to heparin lock with respect to improving TC patency and reducing TC-associated infections. These include citrate, tissue plasminogen activator, and a novel agent containing sodium citrate, methylene blue, methylparaben, and propylparaben. In addition, prophylaxis using oral anticoagulants/antiplatelet agents, including warfarin, aspirin, ticlodipine, as well as the use of modified heparin-coated catheters have also been studied for the prevention of TC dysfunction with variable results. The use of oral anticoagulants and/or antiplatelet agents as primary or secondary prevention of TC dysfunction must be weighed against their potential adverse effects, and should be individualized for each patient. Hindawi Publishing Corporation 2012-02-19 /pmc/articles/PMC3299246/ /pubmed/22518310 http://dx.doi.org/10.1155/2012/170857 Text en Copyright © 2012 Timmy Lee et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Timmy
Lok, Charmaine
Vazquez, Miguel
Moist, Louise
Maya, Ivan
Mokrzycki, Michele
Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention
title Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention
title_full Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention
title_fullStr Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention
title_full_unstemmed Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention
title_short Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention
title_sort minimizing hemodialysis catheter dysfunction: an ounce of prevention
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299246/
https://www.ncbi.nlm.nih.gov/pubmed/22518310
http://dx.doi.org/10.1155/2012/170857
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