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B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha
Chronic hepatitis C (CHC) patients frequently suffer from thyroid disorders during interferon therapy. However, the mechanism remains unclear. In this study, we investigated the association between serum B-cell-activating factor belonging to the TNF family (BAFF) levels and the presence of antithyro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299263/ https://www.ncbi.nlm.nih.gov/pubmed/22481965 http://dx.doi.org/10.1155/2012/247973 |
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author | Kajiyama, Yusuke Kikuchi, Kentaro Takai, Atsuko Hosoya, Naomi Hoshino, Hiromi Hino, Kunihiko Miyakawa, Hiroshi |
author_facet | Kajiyama, Yusuke Kikuchi, Kentaro Takai, Atsuko Hosoya, Naomi Hoshino, Hiromi Hino, Kunihiko Miyakawa, Hiroshi |
author_sort | Kajiyama, Yusuke |
collection | PubMed |
description | Chronic hepatitis C (CHC) patients frequently suffer from thyroid disorders during interferon therapy. However, the mechanism remains unclear. In this study, we investigated the association between serum B-cell-activating factor belonging to the TNF family (BAFF) levels and the presence of antithyroid peroxidase antibody (anti-TPO) in CHC patients treated with pegylated interferon alpha and ribavirin combination therapy. Six months after the therapy, anti-TPO antibody was detected in 10 (males, 1; females, 9) of 50 patients. The mean age of these patients was higher than that of the anti-TPO-negative patients (61 yr versus 55 yr). Before treatment, the serum BAFF levels of the anti-TPO-positive patients were higher than those of the anti-TPO-negative patients. After starting therapy, the serum BAFF levels of both the anti-TPO-positive and -negative patient groups were elevated. Our findings suggest that the serum BAFF concentration before therapy can predict the risk of thyroid autoimmunity in elderly female patients with CHC. |
format | Online Article Text |
id | pubmed-3299263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32992632012-04-05 B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha Kajiyama, Yusuke Kikuchi, Kentaro Takai, Atsuko Hosoya, Naomi Hoshino, Hiromi Hino, Kunihiko Miyakawa, Hiroshi Clin Dev Immunol Research Article Chronic hepatitis C (CHC) patients frequently suffer from thyroid disorders during interferon therapy. However, the mechanism remains unclear. In this study, we investigated the association between serum B-cell-activating factor belonging to the TNF family (BAFF) levels and the presence of antithyroid peroxidase antibody (anti-TPO) in CHC patients treated with pegylated interferon alpha and ribavirin combination therapy. Six months after the therapy, anti-TPO antibody was detected in 10 (males, 1; females, 9) of 50 patients. The mean age of these patients was higher than that of the anti-TPO-negative patients (61 yr versus 55 yr). Before treatment, the serum BAFF levels of the anti-TPO-positive patients were higher than those of the anti-TPO-negative patients. After starting therapy, the serum BAFF levels of both the anti-TPO-positive and -negative patient groups were elevated. Our findings suggest that the serum BAFF concentration before therapy can predict the risk of thyroid autoimmunity in elderly female patients with CHC. Hindawi Publishing Corporation 2012 2012-02-27 /pmc/articles/PMC3299263/ /pubmed/22481965 http://dx.doi.org/10.1155/2012/247973 Text en Copyright © 2012 Yusuke Kajiyama et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kajiyama, Yusuke Kikuchi, Kentaro Takai, Atsuko Hosoya, Naomi Hoshino, Hiromi Hino, Kunihiko Miyakawa, Hiroshi B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha |
title | B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha |
title_full | B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha |
title_fullStr | B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha |
title_full_unstemmed | B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha |
title_short | B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha |
title_sort | b-cell-activating factor affects the occurrence of thyroid autoimmunity in chronic hepatitis c patients treated with interferon alpha |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299263/ https://www.ncbi.nlm.nih.gov/pubmed/22481965 http://dx.doi.org/10.1155/2012/247973 |
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