PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis

PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The m...

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Detalles Bibliográficos
Autores principales: Okumura, Naoko, Yoshida, Hitomi, Kitagishi, Yasuko, Murakami, Mutsumi, Nishimura, Yuri, Matsuda, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299269/
https://www.ncbi.nlm.nih.gov/pubmed/22505939
http://dx.doi.org/10.1155/2012/843085
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author Okumura, Naoko
Yoshida, Hitomi
Kitagishi, Yasuko
Murakami, Mutsumi
Nishimura, Yuri
Matsuda, Satoru
author_facet Okumura, Naoko
Yoshida, Hitomi
Kitagishi, Yasuko
Murakami, Mutsumi
Nishimura, Yuri
Matsuda, Satoru
author_sort Okumura, Naoko
collection PubMed
description PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth. In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis.
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spelling pubmed-32992692012-04-13 PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis Okumura, Naoko Yoshida, Hitomi Kitagishi, Yasuko Murakami, Mutsumi Nishimura, Yuri Matsuda, Satoru Adv Hematol Review Article PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth. In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis. Hindawi Publishing Corporation 2012 2012-02-28 /pmc/articles/PMC3299269/ /pubmed/22505939 http://dx.doi.org/10.1155/2012/843085 Text en Copyright © 2012 Naoko Okumura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Okumura, Naoko
Yoshida, Hitomi
Kitagishi, Yasuko
Murakami, Mutsumi
Nishimura, Yuri
Matsuda, Satoru
PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
title PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
title_full PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
title_fullStr PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
title_full_unstemmed PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
title_short PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
title_sort pi3k/akt/pten signaling as a molecular target in leukemia angiogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299269/
https://www.ncbi.nlm.nih.gov/pubmed/22505939
http://dx.doi.org/10.1155/2012/843085
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