Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles

Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated. In...

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Autores principales: Santin, Giada, Scietti, Luigi, Veneroni, Paola, Barni, Sergio, Bernocchi, Graziella, Bottone, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299333/
https://www.ncbi.nlm.nih.gov/pubmed/22505928
http://dx.doi.org/10.1155/2012/424072
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author Santin, Giada
Scietti, Luigi
Veneroni, Paola
Barni, Sergio
Bernocchi, Graziella
Bottone, Maria Grazia
author_facet Santin, Giada
Scietti, Luigi
Veneroni, Paola
Barni, Sergio
Bernocchi, Graziella
Bottone, Maria Grazia
author_sort Santin, Giada
collection PubMed
description Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated. In particular it has been shown that some organelles are cisPt target and are involved in cell death. This paper aims to describe the morphological and functional changes of the Golgi apparatus and lysosomes during apoptosis induced in neuronal rat cells (B50) by cisplatin. The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death.
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spelling pubmed-32993332012-04-13 Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles Santin, Giada Scietti, Luigi Veneroni, Paola Barni, Sergio Bernocchi, Graziella Bottone, Maria Grazia Int J Cell Biol Research Article Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events involved in the apoptotic process has been demonstrated. In particular it has been shown that some organelles are cisPt target and are involved in cell death. This paper aims to describe the morphological and functional changes of the Golgi apparatus and lysosomes during apoptosis induced in neuronal rat cells (B50) by cisplatin. The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death. Hindawi Publishing Corporation 2012 2012-02-28 /pmc/articles/PMC3299333/ /pubmed/22505928 http://dx.doi.org/10.1155/2012/424072 Text en Copyright © 2012 Giada Santin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Santin, Giada
Scietti, Luigi
Veneroni, Paola
Barni, Sergio
Bernocchi, Graziella
Bottone, Maria Grazia
Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles
title Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles
title_full Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles
title_fullStr Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles
title_full_unstemmed Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles
title_short Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles
title_sort effects of cisplatin in neuroblastoma rat cells: damage to cellular organelles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299333/
https://www.ncbi.nlm.nih.gov/pubmed/22505928
http://dx.doi.org/10.1155/2012/424072
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