A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome

BACKGROUND: The tissue factor (TF)-dependent extrinsic pathway has been suggested to be a central mechanism by which the coagulation cascade is locally activated in the lungs of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) and thus represents an attractive targe...

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Detalles Bibliográficos
Autores principales: Morris, Peter E, Steingrub, Jay S, Huang, Bee Y, Tang, Shamay, Liu, Patrick M, Rhode, Peter R, Wong, Hing C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299584/
https://www.ncbi.nlm.nih.gov/pubmed/22340260
http://dx.doi.org/10.1186/1471-2466-12-5

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