Protein-DNA interactions define the mechanistic aspects of circle formation and insertion reactions in IS2 transposition

BACKGROUND: Transposition in IS3, IS30, IS21 and IS256 insertion sequence (IS) families utilizes an unconventional two-step pathway. A figure-of-eight intermediate in Step I, from asymmetric single-strand cleavage and joining reactions, is converted into a double-stranded minicircle whose junction (...

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Detalles Bibliográficos
Autores principales: Lewis, Leslie A, Astatke, Mekbib, Umekubo, Peter T, Alvi, Shaheen, Saby, Robert, Afrose, Jehan, Oliveira, Pedro H, Monteiro, Gabriel A, Prazeres, Duarte MF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299598/
https://www.ncbi.nlm.nih.gov/pubmed/22277150
http://dx.doi.org/10.1186/1759-8753-3-1

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