Delayed mTOR Inhibition with Low Dose of Everolimus Reduces TGFβ Expression, Attenuates Proteinuria and Renal Damage in the Renal Mass Reduction Model

BACKGROUND: The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migr...

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Detalles Bibliográficos
Autores principales: Kurdián, Melania, Herrero-Fresneda, Inmaculada, Lloberas, Nuria, Gimenez-Bonafe, Pepita, Coria, Virginia, Grande, María T., Boggia, José, Malacrida, Leonel, Torras, Joan, Arévalo, Miguel A., González-Martínez, Francisco, López-Novoa, José M., Grinyó, Josep, Noboa, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299670/
https://www.ncbi.nlm.nih.gov/pubmed/22427849
http://dx.doi.org/10.1371/journal.pone.0032516

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