Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

Although there is no shortage of potential drug targets, there are only a handful known low-molecular-weight inhibitors of protein-protein interactions (PPIs). One problem is that current efforts are dominated by low-yield high-throughput screening, whose rigid framework is not suitable for the dive...

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Detalles Bibliográficos
Autores principales: Koes, David, Khoury, Kareem, Huang, Yijun, Wang, Wei, Bista, Michal, Popowicz, Grzegorz M., Wolf, Siglinde, Holak, Tad A., Dömling, Alexander, Camacho, Carlos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299697/
https://www.ncbi.nlm.nih.gov/pubmed/22427896
http://dx.doi.org/10.1371/journal.pone.0032839

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