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Functional Connectivity of Pain-Mediated Affect Regulation in Borderline Personality Disorder

Affective instability and self-injurious behavior are important features of Borderline Personality Disorder. Whereas affective instability may be caused by a pattern of limbic hyperreactivity paired with dysfunctional prefrontal regulation mechanisms, painful stimulation was found to reduce affectiv...

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Autores principales: Niedtfeld, Inga, Kirsch, Peter, Schulze, Lars, Herpertz, Sabine C., Bohus, Martin, Schmahl, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299768/
https://www.ncbi.nlm.nih.gov/pubmed/22428013
http://dx.doi.org/10.1371/journal.pone.0033293
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author Niedtfeld, Inga
Kirsch, Peter
Schulze, Lars
Herpertz, Sabine C.
Bohus, Martin
Schmahl, Christian
author_facet Niedtfeld, Inga
Kirsch, Peter
Schulze, Lars
Herpertz, Sabine C.
Bohus, Martin
Schmahl, Christian
author_sort Niedtfeld, Inga
collection PubMed
description Affective instability and self-injurious behavior are important features of Borderline Personality Disorder. Whereas affective instability may be caused by a pattern of limbic hyperreactivity paired with dysfunctional prefrontal regulation mechanisms, painful stimulation was found to reduce affective arousal at the neural level, possibly underlying the soothing effect of pain in BPD. We used psychophysiological interactions to analyze functional connectivity of (para-) limbic brain structures (i.e. amygdala, insula, anterior cingulate cortex) in Borderline Personality Disorder in response to painful stimulation. Therefore, we re-analyzed a dataset from 20 patients with Borderline Personality Disorder and 23 healthy controls who took part in an fMRI-task inducing negative (versus neutral) affect and subsequently applying heat pain (versus warmth perception). Results suggest an enhanced negative coupling between limbic as well as paralimbic regions and prefrontal regions, specifically with the medial and dorsolateral prefrontal cortex, when patients experienced pain in addition to emotional arousing pictures. When neutral pictures were combined with painful heat sensation, we found positive connectivity in Borderline Personality Disorder between (para-)limbic brain areas and parts of the basal ganglia (lentiform nucleus, putamen), as well areas involved in self-referential processing (precuneus and posterior cingulate). We found further evidence for alterations in the emotion regulation process in Borderline Personality Disorder, in the way that pain improves the inhibition of limbic activity by prefrontal areas. This study provides new insights in pain processing in BPD, including enhanced coupling of limbic structures and basal ganglia.
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spelling pubmed-32997682012-03-16 Functional Connectivity of Pain-Mediated Affect Regulation in Borderline Personality Disorder Niedtfeld, Inga Kirsch, Peter Schulze, Lars Herpertz, Sabine C. Bohus, Martin Schmahl, Christian PLoS One Research Article Affective instability and self-injurious behavior are important features of Borderline Personality Disorder. Whereas affective instability may be caused by a pattern of limbic hyperreactivity paired with dysfunctional prefrontal regulation mechanisms, painful stimulation was found to reduce affective arousal at the neural level, possibly underlying the soothing effect of pain in BPD. We used psychophysiological interactions to analyze functional connectivity of (para-) limbic brain structures (i.e. amygdala, insula, anterior cingulate cortex) in Borderline Personality Disorder in response to painful stimulation. Therefore, we re-analyzed a dataset from 20 patients with Borderline Personality Disorder and 23 healthy controls who took part in an fMRI-task inducing negative (versus neutral) affect and subsequently applying heat pain (versus warmth perception). Results suggest an enhanced negative coupling between limbic as well as paralimbic regions and prefrontal regions, specifically with the medial and dorsolateral prefrontal cortex, when patients experienced pain in addition to emotional arousing pictures. When neutral pictures were combined with painful heat sensation, we found positive connectivity in Borderline Personality Disorder between (para-)limbic brain areas and parts of the basal ganglia (lentiform nucleus, putamen), as well areas involved in self-referential processing (precuneus and posterior cingulate). We found further evidence for alterations in the emotion regulation process in Borderline Personality Disorder, in the way that pain improves the inhibition of limbic activity by prefrontal areas. This study provides new insights in pain processing in BPD, including enhanced coupling of limbic structures and basal ganglia. Public Library of Science 2012-03-12 /pmc/articles/PMC3299768/ /pubmed/22428013 http://dx.doi.org/10.1371/journal.pone.0033293 Text en Niedtfeld et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Niedtfeld, Inga
Kirsch, Peter
Schulze, Lars
Herpertz, Sabine C.
Bohus, Martin
Schmahl, Christian
Functional Connectivity of Pain-Mediated Affect Regulation in Borderline Personality Disorder
title Functional Connectivity of Pain-Mediated Affect Regulation in Borderline Personality Disorder
title_full Functional Connectivity of Pain-Mediated Affect Regulation in Borderline Personality Disorder
title_fullStr Functional Connectivity of Pain-Mediated Affect Regulation in Borderline Personality Disorder
title_full_unstemmed Functional Connectivity of Pain-Mediated Affect Regulation in Borderline Personality Disorder
title_short Functional Connectivity of Pain-Mediated Affect Regulation in Borderline Personality Disorder
title_sort functional connectivity of pain-mediated affect regulation in borderline personality disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299768/
https://www.ncbi.nlm.nih.gov/pubmed/22428013
http://dx.doi.org/10.1371/journal.pone.0033293
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