The Toxicity of a Mutant Prion Protein Is Cell-Autonomous, and Can Be Suppressed by Wild-Type Prion Protein on Adjacent Cells

Insight into the normal function of PrP(C), and how it can be subverted to produce neurotoxic effects, is provided by PrP molecules carrying deletions encompassing the conserved central region. The most neurotoxic of these mutants, Δ105–125 (called ΔCR), produces a spontaneous neurodegenerative illn...

Descripción completa

Detalles Bibliográficos
Autores principales: Biasini, Emiliano, Turnbaugh, Jessie A., Massignan, Tania, Veglianese, Pietro, Forloni, Gianluigi, Bonetto, Valentina, Chiesa, Roberto, Harris, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299791/
https://www.ncbi.nlm.nih.gov/pubmed/22428057
http://dx.doi.org/10.1371/journal.pone.0033472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299791/
https://www.ncbi.nlm.nih.gov/pubmed/22428057
http://dx.doi.org/10.1371/journal.pone.0033472

Ejemplares similares