Long-term lead elimination from plasma and whole blood after poisoning

OBJECTIVE: Blood lead (B–Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P–Pb) is more adequate. METHODS: A long-term follow-up study of five cases of lead poisoning. P–Pb was analysed by inductively coupled...

Descripción completa

Detalles Bibliográficos
Autores principales: Rentschler, Gerda, Broberg, K., Lundh, T., Skerfving, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299963/
https://www.ncbi.nlm.nih.gov/pubmed/21701834
http://dx.doi.org/10.1007/s00420-011-0673-0
Descripción
Sumario:OBJECTIVE: Blood lead (B–Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P–Pb) is more adequate. METHODS: A long-term follow-up study of five cases of lead poisoning. P–Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled. RESULTS: P–Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P–Pb was about 1 month; B–Pb decay was much slower. CONCLUSION: P–Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

Ejemplares similares