Long-term lead elimination from plasma and whole blood after poisoning

OBJECTIVE: Blood lead (B–Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P–Pb) is more adequate. METHODS: A long-term follow-up study of five cases of lead poisoning. P–Pb was analysed by inductively coupled...

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Detalles Bibliográficos
Autores principales: Rentschler, Gerda, Broberg, K., Lundh, T., Skerfving, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299963/
https://www.ncbi.nlm.nih.gov/pubmed/21701834
http://dx.doi.org/10.1007/s00420-011-0673-0
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author Rentschler, Gerda
Broberg, K.
Lundh, T.
Skerfving, S.
author_facet Rentschler, Gerda
Broberg, K.
Lundh, T.
Skerfving, S.
author_sort Rentschler, Gerda
collection PubMed
description OBJECTIVE: Blood lead (B–Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P–Pb) is more adequate. METHODS: A long-term follow-up study of five cases of lead poisoning. P–Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled. RESULTS: P–Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P–Pb was about 1 month; B–Pb decay was much slower. CONCLUSION: P–Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
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spelling pubmed-32999632012-03-22 Long-term lead elimination from plasma and whole blood after poisoning Rentschler, Gerda Broberg, K. Lundh, T. Skerfving, S. Int Arch Occup Environ Health Original Article OBJECTIVE: Blood lead (B–Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P–Pb) is more adequate. METHODS: A long-term follow-up study of five cases of lead poisoning. P–Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled. RESULTS: P–Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P–Pb was about 1 month; B–Pb decay was much slower. CONCLUSION: P–Pb is a valuable biomarker of exposure to and risk, particularly at high exposure. Springer-Verlag 2011-06-24 2012 /pmc/articles/PMC3299963/ /pubmed/21701834 http://dx.doi.org/10.1007/s00420-011-0673-0 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Rentschler, Gerda
Broberg, K.
Lundh, T.
Skerfving, S.
Long-term lead elimination from plasma and whole blood after poisoning
title Long-term lead elimination from plasma and whole blood after poisoning
title_full Long-term lead elimination from plasma and whole blood after poisoning
title_fullStr Long-term lead elimination from plasma and whole blood after poisoning
title_full_unstemmed Long-term lead elimination from plasma and whole blood after poisoning
title_short Long-term lead elimination from plasma and whole blood after poisoning
title_sort long-term lead elimination from plasma and whole blood after poisoning
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299963/
https://www.ncbi.nlm.nih.gov/pubmed/21701834
http://dx.doi.org/10.1007/s00420-011-0673-0
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AT brobergk longtermleadeliminationfromplasmaandwholebloodafterpoisoning
AT lundht longtermleadeliminationfromplasmaandwholebloodafterpoisoning
AT skerfvings longtermleadeliminationfromplasmaandwholebloodafterpoisoning

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