Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices

This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly. High-resolution structural investigations reveal the diversity and complexity of assemblies formed by these bioinspired amphiphiles, resulting from the interplay between aggregation of t...

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Detalles Bibliográficos
Autores principales: Allain, Vanessa, Bourgaux, Claudie, Couvreur, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3300006/
https://www.ncbi.nlm.nih.gov/pubmed/22075995
http://dx.doi.org/10.1093/nar/gkr681
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author Allain, Vanessa
Bourgaux, Claudie
Couvreur, Patrick
author_facet Allain, Vanessa
Bourgaux, Claudie
Couvreur, Patrick
author_sort Allain, Vanessa
collection PubMed
description This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly. High-resolution structural investigations reveal the diversity and complexity of assemblies formed by these bioinspired amphiphiles, resulting from the interplay between aggregation of the lipid chains and base–base interactions. Nucleolipids supramolecular assemblies are promising soft drug delivery systems, particularly for nucleic acids. Regarding prodrugs, squalenoylation is an innovative concept for improving efficacy and delivery of nucleosidic drugs.
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spelling pubmed-33000062012-03-13 Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices Allain, Vanessa Bourgaux, Claudie Couvreur, Patrick Nucleic Acids Res Survey and Summary This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly. High-resolution structural investigations reveal the diversity and complexity of assemblies formed by these bioinspired amphiphiles, resulting from the interplay between aggregation of the lipid chains and base–base interactions. Nucleolipids supramolecular assemblies are promising soft drug delivery systems, particularly for nucleic acids. Regarding prodrugs, squalenoylation is an innovative concept for improving efficacy and delivery of nucleosidic drugs. Oxford University Press 2012-03 2011-11-09 /pmc/articles/PMC3300006/ /pubmed/22075995 http://dx.doi.org/10.1093/nar/gkr681 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Survey and Summary
Allain, Vanessa
Bourgaux, Claudie
Couvreur, Patrick
Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices
title Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices
title_full Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices
title_fullStr Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices
title_full_unstemmed Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices
title_short Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices
title_sort self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3300006/
https://www.ncbi.nlm.nih.gov/pubmed/22075995
http://dx.doi.org/10.1093/nar/gkr681
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