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Insight into trichomonas vaginalis genome evolution through metabolic pathways comparison
Trichomonas vaginalis causes the trichomoniasis, in women and urethritis and prostate cancer in men. Its genome draft published by TIGR in 2007 presents many unusual genomic and biochemical features like, exceptionally large genome size, the presence of hydrogenosome, gene duplication, lateral gene...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Biomedical Informatics
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302000/ https://www.ncbi.nlm.nih.gov/pubmed/22419839 http://dx.doi.org/10.6026/97320630008189 |
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author | Singh, Satendra Singh, Gurmit Sagar, Nitin Yadav, Pramod Kumar Jain, Prashant A Gautam, Budhayash Wadhwa, Gulshan |
author_facet | Singh, Satendra Singh, Gurmit Sagar, Nitin Yadav, Pramod Kumar Jain, Prashant A Gautam, Budhayash Wadhwa, Gulshan |
author_sort | Singh, Satendra |
collection | PubMed |
description | Trichomonas vaginalis causes the trichomoniasis, in women and urethritis and prostate cancer in men. Its genome draft published by TIGR in 2007 presents many unusual genomic and biochemical features like, exceptionally large genome size, the presence of hydrogenosome, gene duplication, lateral gene transfer mechanism and the presence of miRNA. To understand some of genomic features we have performed a comparative analysis of metabolic pathways of the T. vaginalis with other 22 significant common organisms. Enzymes from the biochemical pathways of T. vaginalis and other selected organisms were retrieved from the KEGG metabolic pathway database. The metabolic pathways of T. vaginalis common in other selected organisms were identified. Total 101 enzymes present in different metabolic pathways of T. vaginalis were found to be orthologous by using BLASTP program against the selected organisms. Except two enzymes all identified orthologous enzymes were also identified as paralogous enzymes. Seventy-five of identified enzymes were also identified as essential for the survival of T. vaginalis, while 26 as non-essential. The identified essential enzymes also represent as good candidate for novel drug targets. Interestingly, some of the identified orthologous and paralogous enzymes were found playing significant role in the key metabolic activities while others were found playing active role in the process of pathogenesis. The N-acetylneuraminate lyase was analyzed as the candidate of lateral genes transfer. These findings clearly suggest the active participation of lateral gene transfer and gene duplication during evolution of T. vaginalis from the enteric to the pathogenic urogenital environment. |
format | Online Article Text |
id | pubmed-3302000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-33020002012-03-14 Insight into trichomonas vaginalis genome evolution through metabolic pathways comparison Singh, Satendra Singh, Gurmit Sagar, Nitin Yadav, Pramod Kumar Jain, Prashant A Gautam, Budhayash Wadhwa, Gulshan Bioinformation Hypothesis Trichomonas vaginalis causes the trichomoniasis, in women and urethritis and prostate cancer in men. Its genome draft published by TIGR in 2007 presents many unusual genomic and biochemical features like, exceptionally large genome size, the presence of hydrogenosome, gene duplication, lateral gene transfer mechanism and the presence of miRNA. To understand some of genomic features we have performed a comparative analysis of metabolic pathways of the T. vaginalis with other 22 significant common organisms. Enzymes from the biochemical pathways of T. vaginalis and other selected organisms were retrieved from the KEGG metabolic pathway database. The metabolic pathways of T. vaginalis common in other selected organisms were identified. Total 101 enzymes present in different metabolic pathways of T. vaginalis were found to be orthologous by using BLASTP program against the selected organisms. Except two enzymes all identified orthologous enzymes were also identified as paralogous enzymes. Seventy-five of identified enzymes were also identified as essential for the survival of T. vaginalis, while 26 as non-essential. The identified essential enzymes also represent as good candidate for novel drug targets. Interestingly, some of the identified orthologous and paralogous enzymes were found playing significant role in the key metabolic activities while others were found playing active role in the process of pathogenesis. The N-acetylneuraminate lyase was analyzed as the candidate of lateral genes transfer. These findings clearly suggest the active participation of lateral gene transfer and gene duplication during evolution of T. vaginalis from the enteric to the pathogenic urogenital environment. Biomedical Informatics 2012-02-28 /pmc/articles/PMC3302000/ /pubmed/22419839 http://dx.doi.org/10.6026/97320630008189 Text en © 2012 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited. |
spellingShingle | Hypothesis Singh, Satendra Singh, Gurmit Sagar, Nitin Yadav, Pramod Kumar Jain, Prashant A Gautam, Budhayash Wadhwa, Gulshan Insight into trichomonas vaginalis genome evolution through metabolic pathways comparison |
title | Insight into trichomonas vaginalis genome evolution through metabolic pathways comparison |
title_full | Insight into trichomonas vaginalis genome evolution through metabolic pathways comparison |
title_fullStr | Insight into trichomonas vaginalis genome evolution through metabolic pathways comparison |
title_full_unstemmed | Insight into trichomonas vaginalis genome evolution through metabolic pathways comparison |
title_short | Insight into trichomonas vaginalis genome evolution through metabolic pathways comparison |
title_sort | insight into trichomonas vaginalis genome evolution through metabolic pathways comparison |
topic | Hypothesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302000/ https://www.ncbi.nlm.nih.gov/pubmed/22419839 http://dx.doi.org/10.6026/97320630008189 |
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