Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis

The asymmetric organocatalytic hydrogenation of benzoxazines, quinolines, quinoxalines and 3H-indoles in continuous-flow microreactors has been developed. Reaction monitoring was achieved by using an inline ReactIR flow cell, which allows fast and convenient optimization of reaction parameters. The...

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Detalles Bibliográficos
Autores principales: Rueping, Magnus, Bootwicha, Teerawut, Sugiono, Erli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302093/
https://www.ncbi.nlm.nih.gov/pubmed/22423298
http://dx.doi.org/10.3762/bjoc.8.32
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author Rueping, Magnus
Bootwicha, Teerawut
Sugiono, Erli
author_facet Rueping, Magnus
Bootwicha, Teerawut
Sugiono, Erli
author_sort Rueping, Magnus
collection PubMed
description The asymmetric organocatalytic hydrogenation of benzoxazines, quinolines, quinoxalines and 3H-indoles in continuous-flow microreactors has been developed. Reaction monitoring was achieved by using an inline ReactIR flow cell, which allows fast and convenient optimization of reaction parameters. The reductions proceeded well, and the desired products were isolated in high yields and with excellent enantioselectivities.
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spelling pubmed-33020932012-03-15 Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis Rueping, Magnus Bootwicha, Teerawut Sugiono, Erli Beilstein J Org Chem Full Research Paper The asymmetric organocatalytic hydrogenation of benzoxazines, quinolines, quinoxalines and 3H-indoles in continuous-flow microreactors has been developed. Reaction monitoring was achieved by using an inline ReactIR flow cell, which allows fast and convenient optimization of reaction parameters. The reductions proceeded well, and the desired products were isolated in high yields and with excellent enantioselectivities. Beilstein-Institut 2012-02-23 /pmc/articles/PMC3302093/ /pubmed/22423298 http://dx.doi.org/10.3762/bjoc.8.32 Text en Copyright © 2012, Rueping et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Rueping, Magnus
Bootwicha, Teerawut
Sugiono, Erli
Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
title Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
title_full Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
title_fullStr Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
title_full_unstemmed Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
title_short Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
title_sort continuous-flow catalytic asymmetric hydrogenations: reaction optimization using ftir inline analysis
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302093/
https://www.ncbi.nlm.nih.gov/pubmed/22423298
http://dx.doi.org/10.3762/bjoc.8.32
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AT sugionoerli continuousflowcatalyticasymmetrichydrogenationsreactionoptimizationusingftirinlineanalysis

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