Cargando…

All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

Alzheimer’s disease (AD) is the most common type of senile dementia in aging populations. Amyloid β (Aβ)-mediated dysregulation of ionic homeostasis is the prevailing underlying mechanism leading to synaptic degeneration and neuronal death. Aβ-dependent ionic dysregulation most likely occurs either...

Descripción completa

Detalles Bibliográficos
Autores principales:	Capone, Ricardo, Jang, Hyunbum, Kotler, Samuel A., Connelly, Laura, Teran Arce, Fernando, Ramachandran, Srinivasan, Kagan, Bruce L., Nussinov, Ruth, Lal, Ratnesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302213/ https://www.ncbi.nlm.nih.gov/pubmed/22423218 http://dx.doi.org/10.1021/ct200885r

Ejemplares similares

Probing Structural Features of Alzheimer’s Amyloid-β Pores in Bilayers Using Site-Specific Amino Acid Substitutions
por: Capone, Ricardo, et al.
Publicado: (2012)

Structural Convergence Among Diverse, Toxic β-Sheet Ion Channels
por: Jang, Hyunbum, et al.
Publicado: (2010)

Role of the Fast Kinetics of Pyroglutamate-Modified Amyloid-β Oligomers in Membrane Binding and Membrane Permeability
por: Lee, Joon, et al.
Publicado: (2014)

Activity and Architecture of Pyroglutamate-Modified Amyloid-β (Aβ(pE3-42)) Pores
por: Gillman, Alan L., et al.
Publicado: (2014)

Structure and Permeability of Ion-channels by Integrated AFM and Waveguide TIRF Microscopy
por: Ramachandran, Srinivasan, et al.
Publicado: (2014)

Conformational study of the protegrin-1 (PG-1) dimer interaction with lipid bilayers and its effect
por: Jang, Hyunbum, et al.
Publicado: (2007)

Ion Channel Formation by Tau Protein: Implications for Alzheimer’s Disease and Tauopathies
por: Patel, Nirav, et al.
Publicado: (2015)

Insulated Conducting Cantilevered Nanotips and Two-Chamber Recording System for High Resolution Ion Sensing AFM
por: Meckes, Brian, et al.
Publicado: (2014)

Multidimensional Atomic Force Microscopy: A Versatile Novel Technology for Nanopharmacology Research
por: Lal, Ratnesh, et al.
Publicado: (2010)

The mechanism of PI3Kα activation at the atomic level
por: Zhang, Mingzhen, et al.
Publicado: (2019)

PI3K inhibitors: review and new strategies
por: Zhang, Mingzhen, et al.
Publicado: (2020)

The quaternary assembly of KRas4B with Raf-1 at the membrane
por: Jang, Hyunbum, et al.
Publicado: (2020)

Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics
por: Haspel, Nurit, et al.
Publicado: (2021)

The structural basis for cancer treatment decisions
por: Nussinov, Ruth, et al.
Publicado: (2014)

Protein ensembles link genotype to phenotype
por: Nussinov, Ruth, et al.
Publicado: (2019)

Does Ras Activate Raf and PI3K Allosterically?
por: Nussinov, Ruth, et al.
Publicado: (2019)

How can same-gene mutations promote both cancer and developmental disorders?
por: Nussinov, Ruth, et al.
Publicado: (2022)

Neurodevelopmental disorders, immunity, and cancer are connected
por: Nussinov, Ruth, et al.
Publicado: (2022)

A New View of Activating Mutations in Cancer
por: Nussinov, Ruth, et al.
Publicado: (2022)

Scavenging amyloid oligomers from neurons with silica nanobowls: Implications for amyloid diseases
por: Sant, Vrinda, et al.
Publicado: (2021)

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B
por: Lu, Shaoyong, et al.
Publicado: (2016)

Ras isoform-specific expression, chromatin accessibility, and signaling
por: Nussinov, Ruth, et al.
Publicado: (2021)

The mechanism of Raf activation through dimerization
por: Zhang, Mingzhen, et al.
Publicado: (2021)

AlphaFold, Artificial Intelligence (AI), and Allostery
por: Nussinov, Ruth, et al.
Publicado: (2022)

Higher‐order interactions of Bcr‐Abl can broaden chronic myeloid leukemia (CML) drug repertoire
por: Liu, Yonglan, et al.
Publicado: (2023)

Strategy toward Kinase-Selective Drug Discovery
por: Zhang, Mingzhen, et al.
Publicado: (2023)

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2
por: Zhang, Wengang, et al.
Publicado: (2023)

Protein conformational ensembles in function: roles and mechanisms
por: Nussinov, Ruth, et al.
Publicado: (2023)

High performance, LED powered, waveguide based total internal reflection microscopy
por: Ramachandran, Srinivasan, et al.
Publicado: (2013)

Atomic Force Microscopy Shows Connexin26 Hemichannel Clustering in Purified Membrane Fragments
por: Meckes, Brian, et al.
Publicado: (2014)

Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers
por: Nussinov, Ruth, et al.
Publicado: (2019)

Computational Structural Biology: Successes, Future Directions, and Challenges
por: Nussinov, Ruth, et al.
Publicado: (2019)

Precision medicine review: rare driver mutations and their biophysical classification
por: Nussinov, Ruth, et al.
Publicado: (2019)

Correction: Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers
por: Nussinov, Ruth, et al.
Publicado: (2019)

The mechanism of activation of monomeric B-Raf V600E
por: Maloney, Ryan C., et al.
Publicado: (2021)

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
por: Jang, Hyunbum, et al.
Publicado: (2021)

How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain
por: Jang, Hyunbum, et al.
Publicado: (2023)

Modulation of calcium channels in arterial smooth muscle cells by dihydropyridine enantiomers
Publicado: (1993)

Clostridium perfringens Enterotoxin: The Toxin Forms Highly Cation-Selective Channels in Lipid Bilayers
por: Benz, Roland, et al.
Publicado: (2018)

A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings
por: Hirano, Minako, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tqif5oibddea5bhavuji0t6f8m