Non-canonical alternatives: What a macrophage is 4

Macrophages play pleiotropic, niche-specific roles in all tissues and organs. As immune sentinels, tissue macrophages regulate immune activation and inflammation; in turn, their function is modulated by inflammatory mediators deriving from such activation. Recent papers have established unanticipate...

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Detalles Bibliográficos
Autores principales: Karp, Christopher L., Murray, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302218/
https://www.ncbi.nlm.nih.gov/pubmed/22412174
http://dx.doi.org/10.1084/jem.20120295
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author Karp, Christopher L.
Murray, Peter J.
author_facet Karp, Christopher L.
Murray, Peter J.
author_sort Karp, Christopher L.
collection PubMed
description Macrophages play pleiotropic, niche-specific roles in all tissues and organs. As immune sentinels, tissue macrophages regulate immune activation and inflammation; in turn, their function is modulated by inflammatory mediators deriving from such activation. Recent papers have established unanticipated roles for interleukin 4 and the alternative activation of tissue macrophages in the organismal response to diverse environmental stressors.
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spelling pubmed-33022182012-09-12 Non-canonical alternatives: What a macrophage is 4 Karp, Christopher L. Murray, Peter J. J Exp Med Perspective Macrophages play pleiotropic, niche-specific roles in all tissues and organs. As immune sentinels, tissue macrophages regulate immune activation and inflammation; in turn, their function is modulated by inflammatory mediators deriving from such activation. Recent papers have established unanticipated roles for interleukin 4 and the alternative activation of tissue macrophages in the organismal response to diverse environmental stressors. The Rockefeller University Press 2012-03-12 /pmc/articles/PMC3302218/ /pubmed/22412174 http://dx.doi.org/10.1084/jem.20120295 Text en © 2012 Karp and Murray This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Perspective
Karp, Christopher L.
Murray, Peter J.
Non-canonical alternatives: What a macrophage is 4
title Non-canonical alternatives: What a macrophage is 4
title_full Non-canonical alternatives: What a macrophage is 4
title_fullStr Non-canonical alternatives: What a macrophage is 4
title_full_unstemmed Non-canonical alternatives: What a macrophage is 4
title_short Non-canonical alternatives: What a macrophage is 4
title_sort non-canonical alternatives: what a macrophage is 4
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302218/
https://www.ncbi.nlm.nih.gov/pubmed/22412174
http://dx.doi.org/10.1084/jem.20120295
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