HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

After tissue damage, inflammatory cells infiltrate the tissue and release proinflammatory cytokines. HMGB1 (high mobility group box 1), a nuclear protein released by necrotic and severely stressed cells, promotes cytokine release via its interaction with the TLR4 (Toll-like receptor 4) receptor and...

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Detalles Bibliográficos
Autores principales: Schiraldi, Milena, Raucci, Angela, Muñoz, Laura Martínez, Livoti, Elsa, Celona, Barbara, Venereau, Emilie, Apuzzo, Tiziana, De Marchis, Francesco, Pedotti, Mattia, Bachi, Angela, Thelen, Marcus, Varani, Luca, Mellado, Mario, Proudfoot, Amanda, Bianchi, Marco Emilio, Uguccioni, Mariagrazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302219/
https://www.ncbi.nlm.nih.gov/pubmed/22370717
http://dx.doi.org/10.1084/jem.20111739

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