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Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior

BACKGROUND: Arsenic is an environmental pollutant, potent human toxicant, and oxidative stress agent with a multiplicity of health effects associated with both acute and chronic exposures. A semi-mechanistic cellular-level toxicokinetic (TK) model was developed in order to describe the uptake, biotr...

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Detalles Bibliográficos
Autores principales:	Stamatelos, Spyros K, Brinkerhoff, Christopher J, Isukapalli, Sastry S, Georgopoulos, Panos G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302683/ https://www.ncbi.nlm.nih.gov/pubmed/21266075 http://dx.doi.org/10.1186/1752-0509-5-16

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