Cargando…

Postprandial metabolic heterogeneity in men with primary dyslipidaemia

INTRODUCTION: Familial combined hyperlipidaemia (FCH) and familial hypercholesterolaemia (FH) have been strongly linked to premature coronary artery disease. Postprandial hypertriglyceridaemia is also associated with atherosclerotic disease. We evaluated the postprandial lipaemia in men with FCH and...

Descripción completa

Detalles Bibliográficos
Autores principales: Pavlidis, Antonios N., Kolovou, Genovefa D., Anagnostopoulou, Katherine K., Petrou, Petros C., Cokkinos, Dennis V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302699/
https://www.ncbi.nlm.nih.gov/pubmed/22427761
http://dx.doi.org/10.5114/aoms.2010.19295
_version_ 1782226658915254272
author Pavlidis, Antonios N.
Kolovou, Genovefa D.
Anagnostopoulou, Katherine K.
Petrou, Petros C.
Cokkinos, Dennis V.
author_facet Pavlidis, Antonios N.
Kolovou, Genovefa D.
Anagnostopoulou, Katherine K.
Petrou, Petros C.
Cokkinos, Dennis V.
author_sort Pavlidis, Antonios N.
collection PubMed
description INTRODUCTION: Familial combined hyperlipidaemia (FCH) and familial hypercholesterolaemia (FH) have been strongly linked to premature coronary artery disease. Postprandial hypertriglyceridaemia is also associated with atherosclerotic disease. We evaluated the postprandial lipaemia in men with FCH and FH and compared them to a group of healthy men. MATERIAL AND METHODS: The study population consisted of 83 men: 34 FCH, 29 FH and 20 healthy. The FCH and FH groups were further divided into five subgroups, according to their lipid phenotype: FCH-IIA (n = 13), FCH-IIB (n = 10), FCH-IV (n = 11), FH-IIA (n = 21) and FH-IIB (n = 8). Postprandial lipaemia was evaluated by the areas under the curve for triglyceride (TG) concentrations (TG-AUC). RESULTS: The TG levels after oral fat tolerance test were significantly higher in FCH, compared to FH and healthy groups (TG-AUC in mg/dl/h; 2678 ±1415 vs. 1503 ±1147 and 1011 ±652 respectively, p < 0.001). The postprandial response was higher in FCH-IV and FCH-IIB, compared to FCH-IIA (TG-AUC in mg/dl/h; 3220 ±824 or 3409 ±770 vs. 1863 ±577 respectively, p < 0.001, for both comparisons). The FCH-IIA group showed higher postprandial TG levels when compared to FH-IIA (TG-AUC in mg/dl/h; 1863 ±577 vs. 1374 ±428 respectively, p = 0.008). There were no significant differences between FH-IIB and FCH-IIB subgroups. There was a significant correlation (r = 0.907, p < 0.001) between the postprandial TG-AUC and fasting TG levels in all FCH subjects. CONCLUSIONS: All phenotypes of FCH and the FH IIB phenotype demonstrate an exaggerated postprandial response that could partially contribute to the high cardiovascular risk. These patients should be identified and treated early with the appropriate hypolipidaemic agents.
format Online
Article
Text
id pubmed-3302699
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-33026992012-03-16 Postprandial metabolic heterogeneity in men with primary dyslipidaemia Pavlidis, Antonios N. Kolovou, Genovefa D. Anagnostopoulou, Katherine K. Petrou, Petros C. Cokkinos, Dennis V. Arch Med Sci Clinical Research INTRODUCTION: Familial combined hyperlipidaemia (FCH) and familial hypercholesterolaemia (FH) have been strongly linked to premature coronary artery disease. Postprandial hypertriglyceridaemia is also associated with atherosclerotic disease. We evaluated the postprandial lipaemia in men with FCH and FH and compared them to a group of healthy men. MATERIAL AND METHODS: The study population consisted of 83 men: 34 FCH, 29 FH and 20 healthy. The FCH and FH groups were further divided into five subgroups, according to their lipid phenotype: FCH-IIA (n = 13), FCH-IIB (n = 10), FCH-IV (n = 11), FH-IIA (n = 21) and FH-IIB (n = 8). Postprandial lipaemia was evaluated by the areas under the curve for triglyceride (TG) concentrations (TG-AUC). RESULTS: The TG levels after oral fat tolerance test were significantly higher in FCH, compared to FH and healthy groups (TG-AUC in mg/dl/h; 2678 ±1415 vs. 1503 ±1147 and 1011 ±652 respectively, p < 0.001). The postprandial response was higher in FCH-IV and FCH-IIB, compared to FCH-IIA (TG-AUC in mg/dl/h; 3220 ±824 or 3409 ±770 vs. 1863 ±577 respectively, p < 0.001, for both comparisons). The FCH-IIA group showed higher postprandial TG levels when compared to FH-IIA (TG-AUC in mg/dl/h; 1863 ±577 vs. 1374 ±428 respectively, p = 0.008). There were no significant differences between FH-IIB and FCH-IIB subgroups. There was a significant correlation (r = 0.907, p < 0.001) between the postprandial TG-AUC and fasting TG levels in all FCH subjects. CONCLUSIONS: All phenotypes of FCH and the FH IIB phenotype demonstrate an exaggerated postprandial response that could partially contribute to the high cardiovascular risk. These patients should be identified and treated early with the appropriate hypolipidaemic agents. Termedia Publishing House 2010-12 2010-12-29 /pmc/articles/PMC3302699/ /pubmed/22427761 http://dx.doi.org/10.5114/aoms.2010.19295 Text en Copyright © 2010 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Pavlidis, Antonios N.
Kolovou, Genovefa D.
Anagnostopoulou, Katherine K.
Petrou, Petros C.
Cokkinos, Dennis V.
Postprandial metabolic heterogeneity in men with primary dyslipidaemia
title Postprandial metabolic heterogeneity in men with primary dyslipidaemia
title_full Postprandial metabolic heterogeneity in men with primary dyslipidaemia
title_fullStr Postprandial metabolic heterogeneity in men with primary dyslipidaemia
title_full_unstemmed Postprandial metabolic heterogeneity in men with primary dyslipidaemia
title_short Postprandial metabolic heterogeneity in men with primary dyslipidaemia
title_sort postprandial metabolic heterogeneity in men with primary dyslipidaemia
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302699/
https://www.ncbi.nlm.nih.gov/pubmed/22427761
http://dx.doi.org/10.5114/aoms.2010.19295
work_keys_str_mv AT pavlidisantoniosn postprandialmetabolicheterogeneityinmenwithprimarydyslipidaemia
AT kolovougenovefad postprandialmetabolicheterogeneityinmenwithprimarydyslipidaemia
AT anagnostopouloukatherinek postprandialmetabolicheterogeneityinmenwithprimarydyslipidaemia
AT petroupetrosc postprandialmetabolicheterogeneityinmenwithprimarydyslipidaemia
AT cokkinosdennisv postprandialmetabolicheterogeneityinmenwithprimarydyslipidaemia