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Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma
INTRODUCTION: Common medications used to treat mild persistent asthma are glucocorticoids, leukotriene receptor antagonists and theophylline. The aim of the study was to evaluate monotherapy with either inhaled steroids, oral leukotriene receptor antagonist or theophylline in Egyptian children with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302705/ https://www.ncbi.nlm.nih.gov/pubmed/22427767 http://dx.doi.org/10.5114/aoms.2010.19302 |
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author | Radwan, Zeinab Mohamed Nasser Yamamah, Gamal Abdel Shaaban, Hala Hamdy Omar Abdel-Rahman, Azza Mohamed Abdel-Ghany Ismaeil, Amany Mohamed Mostafa, Elham |
author_facet | Radwan, Zeinab Mohamed Nasser Yamamah, Gamal Abdel Shaaban, Hala Hamdy Omar Abdel-Rahman, Azza Mohamed Abdel-Ghany Ismaeil, Amany Mohamed Mostafa, Elham |
author_sort | Radwan, Zeinab Mohamed |
collection | PubMed |
description | INTRODUCTION: Common medications used to treat mild persistent asthma are glucocorticoids, leukotriene receptor antagonists and theophylline. The aim of the study was to evaluate monotherapy with either inhaled steroids, oral leukotriene receptor antagonist or theophylline in Egyptian children with mild persistent asthma by determining their clinical, laboratory and spirometric responses to treatment. MATERIAL AND METHODS: Thirty-nine mild asthmatic children between 8 and 13 years of age were included in the study. Patients were classified according to therapy received into four groups: oral leukotriene receptor antagonist (montelukast), inhaled corticosteroid (fluticasone propionate), sustained-release (SR) theophylline, and no treatment. Pulmonary function testing was performed at the start of therapy and 8 weeks later using spirometry. Eosinophil count and serum nitric oxide were estimated in the blood. Minitab statistical package was used for analysis of data. RESULTS: Follow-up after 8 weeks revealed significant improvement in FEV1% in groups 1 (p < 0.01) and 3 (p < 0.05), significant improvement in PEFR in groups 1 (p < 0.05) and 2 (p < 0.01), significant decline in serum NO levels in groups 1 (p < 0.05) and 2 (p < 0.05), as well as significant improvement in eosinophil count in groups 1, 2 and 3 (p < 0.01, < 0.001, < 0.01 respectively). There was a statistically significant positive correlation between the decline in serum NO and the decline in blood eosinophil % in group 2 (p < 0.05). CONCLUSIONS: Inhaled corticosteroids and montelukast have a significant role in controlling the pulmonary functions and the inflammatory process in children with mild persistent asthma, although inhaled corticosteroids seem to yield a better response. Children with mild persistent asthma should receive a controller medication, and SR theophylline may be a good cost-benefit alternative for low socio-economic groups of patients. |
format | Online Article Text |
id | pubmed-3302705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-33027052012-03-16 Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma Radwan, Zeinab Mohamed Nasser Yamamah, Gamal Abdel Shaaban, Hala Hamdy Omar Abdel-Rahman, Azza Mohamed Abdel-Ghany Ismaeil, Amany Mohamed Mostafa, Elham Arch Med Sci Clinical Research INTRODUCTION: Common medications used to treat mild persistent asthma are glucocorticoids, leukotriene receptor antagonists and theophylline. The aim of the study was to evaluate monotherapy with either inhaled steroids, oral leukotriene receptor antagonist or theophylline in Egyptian children with mild persistent asthma by determining their clinical, laboratory and spirometric responses to treatment. MATERIAL AND METHODS: Thirty-nine mild asthmatic children between 8 and 13 years of age were included in the study. Patients were classified according to therapy received into four groups: oral leukotriene receptor antagonist (montelukast), inhaled corticosteroid (fluticasone propionate), sustained-release (SR) theophylline, and no treatment. Pulmonary function testing was performed at the start of therapy and 8 weeks later using spirometry. Eosinophil count and serum nitric oxide were estimated in the blood. Minitab statistical package was used for analysis of data. RESULTS: Follow-up after 8 weeks revealed significant improvement in FEV1% in groups 1 (p < 0.01) and 3 (p < 0.05), significant improvement in PEFR in groups 1 (p < 0.05) and 2 (p < 0.01), significant decline in serum NO levels in groups 1 (p < 0.05) and 2 (p < 0.05), as well as significant improvement in eosinophil count in groups 1, 2 and 3 (p < 0.01, < 0.001, < 0.01 respectively). There was a statistically significant positive correlation between the decline in serum NO and the decline in blood eosinophil % in group 2 (p < 0.05). CONCLUSIONS: Inhaled corticosteroids and montelukast have a significant role in controlling the pulmonary functions and the inflammatory process in children with mild persistent asthma, although inhaled corticosteroids seem to yield a better response. Children with mild persistent asthma should receive a controller medication, and SR theophylline may be a good cost-benefit alternative for low socio-economic groups of patients. Termedia Publishing House 2010-12 2010-12-29 /pmc/articles/PMC3302705/ /pubmed/22427767 http://dx.doi.org/10.5114/aoms.2010.19302 Text en Copyright © 2010 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Radwan, Zeinab Mohamed Nasser Yamamah, Gamal Abdel Shaaban, Hala Hamdy Omar Abdel-Rahman, Azza Mohamed Abdel-Ghany Ismaeil, Amany Mohamed Mostafa, Elham Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma |
title | Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma |
title_full | Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma |
title_fullStr | Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma |
title_full_unstemmed | Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma |
title_short | Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma |
title_sort | effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302705/ https://www.ncbi.nlm.nih.gov/pubmed/22427767 http://dx.doi.org/10.5114/aoms.2010.19302 |
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