Cargando…

Virologic Failure of Protease Inhibitor-Based Second-Line Antiretroviral Therapy without Resistance in a Large HIV Treatment Program in South Africa

BACKGROUND: We investigated the prevalence of wild-type virus (no major drug resistance) and drug resistance mutations at second-line antiretroviral treatment (ART) failure in a large HIV treatment program in South Africa. METHODOLOGY/ PRINCIPAL FINDINGS: HIV-infected patients ≥15 years of age who h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Levison, Julie H., Orrell, Catherine, Gallien, Sébastien, Kuritzkes, Daniel R., Fu, Naishin, Losina, Elena, Freedberg, Kenneth A., Wood, Robin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302781/ https://www.ncbi.nlm.nih.gov/pubmed/22427821 http://dx.doi.org/10.1371/journal.pone.0032144

Ejemplares similares

Evolution of resistance in paediatric patients with failure on antiretroviral therapy
por: Orrell, C, et al.
Publicado: (2012)

The Survival Benefits of Antiretroviral Therapy in South Africa
por: April, Michael D., et al.
Publicado: (2014)

Increasing Transfers-Out from an Antiretroviral Treatment Service in South Africa: Patient Characteristics and Rates of Virological Non-Suppression
por: Nglazi, Mweete D., et al.
Publicado: (2013)

Pregnancy and Virologic Response to Antiretroviral Therapy in South Africa
por: Westreich, Daniel, et al.
Publicado: (2011)

Sustained Virological Response on Second-Line Antiretroviral Therapy following Virological Failure in HIV-Infected Patients in Rural South Africa
por: Schoffelen, Annelot F., et al.
Publicado: (2013)

Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa
por: Hom, Jeffrey K., et al.
Publicado: (2012)

Linkage to HIV Care and Antiretroviral Therapy in Cape Town, South Africa
por: Kranzer, Katharina, et al.
Publicado: (2010)

Virological Breakthrough: A Risk Factor for Loss to Followup in a Large Community-Based Cohort on Antiretroviral Therapy
por: Orrell, Catherine, et al.
Publicado: (2011)

Second-Line Antiretroviral Therapy in a Workplace and Community-Based Treatment Programme in South Africa: Determinants of Virological Outcome
por: Johnston, Victoria, et al.
Publicado: (2012)

Rates of Switching Antiretroviral Drugs in a Primary Care Service in South Africa before and after Introduction of Tenofovir
por: Njuguna, Christine, et al.
Publicado: (2013)

Public-Health and Individual Approaches to Antiretroviral Therapy: Township South Africa and Switzerland Compared
por: Keiser, Olivia, et al.
Publicado: (2008)

Clinic-Based Urinary Lipoarabinomannan as a Biomarker of Clinical Disease Severity and Mortality Among Antiretroviral Therapy-Naive Human Immunodeficiency Virus-Infected Adults in South Africa
por: Drain, Paul K., et al.
Publicado: (2017)

Correction: Public-Health and Individual Approaches to Antiretroviral Therapy: Township South Africa and Switzerland Compared
por: Keiser, Olivia, et al.
Publicado: (2008)

Pediatric Response to Second-Line Antiretroviral Therapy in South Africa
por: Zanoni, Brian C., et al.
Publicado: (2012)

Risk factors for poor virological outcome at 12 months in a workplace-based antiretroviral therapy programme in South Africa: A cohort study
por: Fielding, Katherine L, et al.
Publicado: (2008)

Temporal Association Between Incident Tuberculosis and Poor Virological Outcomes in a South African Antiretroviral Treatment Service
por: Gupta-Wright, Ankur, et al.
Publicado: (2013)

Mobile HIV Screening in Cape Town, South Africa: Clinical Impact, Cost and Cost-Effectiveness
por: Bassett, Ingrid V., et al.
Publicado: (2014)

Not All Are Lost: Interrupted Laboratory Monitoring, Early Death, and Loss to Follow-Up (LTFU) in a Large South African Treatment Program
por: Ahonkhai, Aima A., et al.
Publicado: (2012)

Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa
por: Badri, Motasim, et al.
Publicado: (2006)

Virologic outcomes of second-line antiretroviral therapy in Eastern European country of Georgia
por: Chkhartishvili, Nikoloz, et al.
Publicado: (2014)

The Clinical Impact and Cost-Effectiveness of Clinic-Based Cognitive Behavioral Therapy for People With HIV, Depression, and Virologic Failure in South Africa
por: Gandhi, Aditya R., et al.
Publicado: (2023)

Antiretroviral therapy uptake and predictors of virological failure in patients with HIV receiving first-line and second-line regimens in Johannesburg, South Africa: a retrospective cohort data analysis
por: Gumede, Siphamandla Bonga, et al.
Publicado: (2022)

Linkage to care, mobility and retention of HIV‐positive postpartum women in antiretroviral therapy services in South Africa
por: Phillips, Tamsin K, et al.
Publicado: (2018)

Impact of Medication Adherence on Virologic Failure in A5202: A Randomized, Partially Blinded, Phase 3B Study
por: Parker, Robert A., et al.
Publicado: (2017)

Twelve-year mortality in adults initiating antiretroviral therapy in South Africa
por: Cornell, Morna, et al.
Publicado: (2017)

Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa
por: Wallis, Carole L., et al.
Publicado: (2011)

High virologic response rate after second-line boosted protease inhibitor-based antiretroviral therapy regimens in children from a resource limited setting
por: Puthanakit, Thanyawee, et al.
Publicado: (2012)

Factors Associated with Self-Reported Repeat HIV Testing after a Negative Result in Durban, South Africa
por: Regan, Susan, et al.
Publicado: (2013)

Adverse Drug Reactions Among Patients Initiating Second-Line Antiretroviral Therapy in South Africa
por: Onoya, Dorina, et al.
Publicado: (2018)

Factors Predicting Discordant Virological and Immunological Responses to Antiretroviral Therapy in HIV-1 Clade C Infected Zulu/Xhosa in South Africa
por: Julg, Boris, et al.
Publicado: (2012)

Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
por: Dugdale, Caitlin M., et al.
Publicado: (2019)

Using national laboratory data to assess cumulative frequency of linkage after transfer to community‐based HIV clinics in South Africa
por: Bassett, Ingrid V, et al.
Publicado: (2019)

Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa
por: Bionghi, N., et al.
Publicado: (2018)

Predicting the Need for Third-Line Antiretroviral Therapy by Identifying Patients at High Risk for Failing Second-Line Antiretroviral Therapy in South Africa
por: Onoya, Dorina, et al.
Publicado: (2017)

Predictors of virologic outcome among people living with HIV who continue a protease inhibitor-based antiretroviral regimen following virologic failure with no or limited resistance
por: Salata, Robert A., et al.
Publicado: (2023)

Risk Factors for Late-Stage HIV Disease Presentation at Initial HIV Diagnosis in Durban, South Africa
por: Drain, Paul K., et al.
Publicado: (2013)

Increased Risk of Virologic Rebound in Patients on Antiviral Therapy with a Detectable HIV Load <48 Copies/mL
por: Henrich, Timothy J., et al.
Publicado: (2012)

Inflammatory biomarkers prior to antiretroviral therapy as prognostic markers of 12-month mortality in South Africa and Uganda
por: Siedner, Mark J., et al.
Publicado: (2019)

Setting Performance Standards for a Cost-Effective Human Immunodeficiency Virus Cure Strategy in South Africa
por: Paltiel, A. David, et al.
Publicado: (2017)

Clinical Benefits and Cost-Effectiveness of Laboratory Monitoring Strategies to Guide Antiretroviral Treatment Switching in India
por: Freedberg, Kenneth A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p9vso3fb3uv9i8c4bdker9hd31