Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity

Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states. Previous studies have functionally implicated the NMDA receptor-NO pathway and...

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Detalles Bibliográficos
Autores principales: Luo, Ceng, Gangadharan, Vijayan, Bali, Kiran Kumar, Xie, Rou-Gang, Agarwal, Nitin, Kurejova, Martina, Tappe-Theodor, Anke, Tegeder, Irmgard, Feil, Susanne, Lewin, Gary, Polgar, Erika, Todd, Andrew J., Schlossmann, Jens, Hofmann, Franz, Liu, Da-Lu, Hu, San-Jue, Feil, Robert, Kuner, Thomas, Kuner, Rohini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302842/
https://www.ncbi.nlm.nih.gov/pubmed/22427743
http://dx.doi.org/10.1371/journal.pbio.1001283

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