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Activation of PI3K/AKT and MAPK Pathway through a PDGFRβ-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular Carcinoma
BACKGROUND: Rapamycin is an attractive approach for the treatment and prevention of HCC recurrence after liver transplantation. However, the objective response rates of rapamycin achieved with single-agent therapy were modest, supporting that rapamycin resistance is a frequently observed characteris...
Autores principales: | Li, Quan-Lin, Gu, Fang-Ming, Wang, Zheng, Jiang, Jia-Hao, Yao, Li-Qing, Tan, Chang-Jun, Huang, Xiao-Yong, Ke, Ai-Wu, Dai, Zhi, Fan, Jia, Zhou, Jian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302853/ https://www.ncbi.nlm.nih.gov/pubmed/22428038 http://dx.doi.org/10.1371/journal.pone.0033379 |
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