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α-Mangostin Induces Apoptosis and Suppresses Differentiation of 3T3-L1 Cells via Inhibiting Fatty Acid Synthase

α-Mangostin, isolated from the hulls of Garcinia mangostana L., was found to have in vitro cytotoxicity against 3T3-L1 cells as well as inhibiting fatty acid synthase (FAS, EC 2.3.1.85). Our studies showed that the cytotoxicity of α-mangostin with IC(50) value of 20 µM was incomplicated in apoptotic...

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Detalles Bibliográficos
Autores principales:	Quan, Xiaofang, Wang, Yi, Ma, Xiaofeng, Liang, Yan, Tian, Weixi, Ma, Qingyun, Jiang, Hezhong, Zhao, Youxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302861/ https://www.ncbi.nlm.nih.gov/pubmed/22428036 http://dx.doi.org/10.1371/journal.pone.0033376

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