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Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation

Oocyte donors have high serum estradiol (E2) levels similar to the serum levels seen in the first trimester of pregnancy. We report in this article our studies comparing cell proliferation, Ki67 (MIB1), and estrogen and progesterone receptor levels (ERα, PRA, and PRB) in the breast terminal duct lob...

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Autores principales: Chung, Karine, Hovanessian-Larsen, Linda J., Hawes, Debra, Taylor, DeShawn, Downey, Susan, Spicer, Darcy V., Stanczyk, Frank Z., Patel, Sherfaraz, Anderson, A. Rebecca, Pike, Malcolm C., Wu, Anna H., Pearce, Celeste Leigh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303045/
https://www.ncbi.nlm.nih.gov/pubmed/22083231
http://dx.doi.org/10.1007/s10549-011-1870-y
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author Chung, Karine
Hovanessian-Larsen, Linda J.
Hawes, Debra
Taylor, DeShawn
Downey, Susan
Spicer, Darcy V.
Stanczyk, Frank Z.
Patel, Sherfaraz
Anderson, A. Rebecca
Pike, Malcolm C.
Wu, Anna H.
Pearce, Celeste Leigh
author_facet Chung, Karine
Hovanessian-Larsen, Linda J.
Hawes, Debra
Taylor, DeShawn
Downey, Susan
Spicer, Darcy V.
Stanczyk, Frank Z.
Patel, Sherfaraz
Anderson, A. Rebecca
Pike, Malcolm C.
Wu, Anna H.
Pearce, Celeste Leigh
author_sort Chung, Karine
collection PubMed
description Oocyte donors have high serum estradiol (E2) levels similar to the serum levels seen in the first trimester of pregnancy. We report in this article our studies comparing cell proliferation, Ki67 (MIB1), and estrogen and progesterone receptor levels (ERα, PRA, and PRB) in the breast terminal duct lobular units of oocyte donors, women in early pregnancy, and in normally cycling women. Breast tissue and blood samples were obtained from 10 oocyte donors, and 30 pregnant women at 5–18 weeks of gestation. Breast tissue samples were also obtained from 26 normally cycling women. In the oocyte donors: peak E2 (mean ~15,300 pmol/l) was reached on the day before oocyte (and tissue) donation; peak progesterone (P4; mean 36.3 nmol/l) was reached on the day of donation; Ki67 was positively associated with level of E2, and the mean Ki67 was 7.0% significantly greater than the mean 1.8% of cycling women. In the pregnant women: mean E2 rose from ~2,000 pmol/l at 5 weeks of gestation to ~27,000 pmol/l at 18 weeks; mean P4 did not change from ~40 nmol/l until around gestational week 11 when it increased to ~80 nmol/l; mean Ki67 was 15.4% and did not vary with gestational age or E2. Oocyte donors have greatly increased levels of E2 and of breast-cell proliferation, both comparable in the majority of donors to the levels seen in the first trimester of pregnancy. Whether their short durations of greatly increased E2 levels are associated with any long-term beneficial effects on the breast, as occurring in rodent models, is not known.
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spelling pubmed-33030452012-03-22 Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation Chung, Karine Hovanessian-Larsen, Linda J. Hawes, Debra Taylor, DeShawn Downey, Susan Spicer, Darcy V. Stanczyk, Frank Z. Patel, Sherfaraz Anderson, A. Rebecca Pike, Malcolm C. Wu, Anna H. Pearce, Celeste Leigh Breast Cancer Res Treat Epidemiology Oocyte donors have high serum estradiol (E2) levels similar to the serum levels seen in the first trimester of pregnancy. We report in this article our studies comparing cell proliferation, Ki67 (MIB1), and estrogen and progesterone receptor levels (ERα, PRA, and PRB) in the breast terminal duct lobular units of oocyte donors, women in early pregnancy, and in normally cycling women. Breast tissue and blood samples were obtained from 10 oocyte donors, and 30 pregnant women at 5–18 weeks of gestation. Breast tissue samples were also obtained from 26 normally cycling women. In the oocyte donors: peak E2 (mean ~15,300 pmol/l) was reached on the day before oocyte (and tissue) donation; peak progesterone (P4; mean 36.3 nmol/l) was reached on the day of donation; Ki67 was positively associated with level of E2, and the mean Ki67 was 7.0% significantly greater than the mean 1.8% of cycling women. In the pregnant women: mean E2 rose from ~2,000 pmol/l at 5 weeks of gestation to ~27,000 pmol/l at 18 weeks; mean P4 did not change from ~40 nmol/l until around gestational week 11 when it increased to ~80 nmol/l; mean Ki67 was 15.4% and did not vary with gestational age or E2. Oocyte donors have greatly increased levels of E2 and of breast-cell proliferation, both comparable in the majority of donors to the levels seen in the first trimester of pregnancy. Whether their short durations of greatly increased E2 levels are associated with any long-term beneficial effects on the breast, as occurring in rodent models, is not known. Springer US 2011-11-15 2012 /pmc/articles/PMC3303045/ /pubmed/22083231 http://dx.doi.org/10.1007/s10549-011-1870-y Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Epidemiology
Chung, Karine
Hovanessian-Larsen, Linda J.
Hawes, Debra
Taylor, DeShawn
Downey, Susan
Spicer, Darcy V.
Stanczyk, Frank Z.
Patel, Sherfaraz
Anderson, A. Rebecca
Pike, Malcolm C.
Wu, Anna H.
Pearce, Celeste Leigh
Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation
title Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation
title_full Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation
title_fullStr Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation
title_full_unstemmed Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation
title_short Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation
title_sort breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303045/
https://www.ncbi.nlm.nih.gov/pubmed/22083231
http://dx.doi.org/10.1007/s10549-011-1870-y
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