Analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma

KRAS mutation testing is mandatory before prescribing anti-epidermal growth factor monoclonal antibodies in the treatment of advanced colorectal cancer. We describe the performance of a TaqMelt polymerase chain reaction (PCR) assay—the cobas® KRAS Mutation Test—designed to detect 19 mutations in cod...

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Detalles Bibliográficos
Autores principales: Lee, Sung, Brophy, Victoria H., Cao, Jianli, Velez, Margot, Hoeppner, Corey, Soviero, Stephen, Lawrence, H. Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303066/
https://www.ncbi.nlm.nih.gov/pubmed/22173329
http://dx.doi.org/10.1007/s00428-011-1180-0

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