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Genomic Diversification of Enterococci in Hosts: The Role of the Mobilome
Enterococci are ubiquitous lactic acid bacteria, possessing a flexible nature that allows them to colonize various environments and hosts but also to be opportunistic pathogens. Many papers have contributed to a better understanding of: (i) the taxonomy of this complex group of microorganisms; (ii)...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303144/ https://www.ncbi.nlm.nih.gov/pubmed/22435066 http://dx.doi.org/10.3389/fmicb.2012.00095 |
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author | Santagati, Maria Campanile, Floriana Stefani, Stefania |
author_facet | Santagati, Maria Campanile, Floriana Stefani, Stefania |
author_sort | Santagati, Maria |
collection | PubMed |
description | Enterococci are ubiquitous lactic acid bacteria, possessing a flexible nature that allows them to colonize various environments and hosts but also to be opportunistic pathogens. Many papers have contributed to a better understanding of: (i) the taxonomy of this complex group of microorganisms; (ii) intra-species variability; (iii) the role of different pathogenicity traits; and (iv) some markers related to the character of host-specificity, but the reasons of such incredible success of adaptability is still far from being fully explained. Recently, genomic-based studies have improved our understanding of the genome diversity of the most studied species, i.e., E. faecalis and E. faecium. From these studies, what is becoming evident is the role of the mobilome in adding new abilities to colonize new hosts and environments, and eventually in driving their evolution: specific clones associated with human infections or specific hosts can exist, but probably the consideration of these populations as strictly clonal groups is only partially correct. The variable presence of mobile genetic elements may, indeed, be one of the factors involved in the evolution of one specific group in a specific host and/or environment. Certainly more extensive studies using new high throughput technologies are mandatory to fully understand the evolution of predominant clones and species in different hosts and environments. |
format | Online Article Text |
id | pubmed-3303144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33031442012-03-20 Genomic Diversification of Enterococci in Hosts: The Role of the Mobilome Santagati, Maria Campanile, Floriana Stefani, Stefania Front Microbiol Microbiology Enterococci are ubiquitous lactic acid bacteria, possessing a flexible nature that allows them to colonize various environments and hosts but also to be opportunistic pathogens. Many papers have contributed to a better understanding of: (i) the taxonomy of this complex group of microorganisms; (ii) intra-species variability; (iii) the role of different pathogenicity traits; and (iv) some markers related to the character of host-specificity, but the reasons of such incredible success of adaptability is still far from being fully explained. Recently, genomic-based studies have improved our understanding of the genome diversity of the most studied species, i.e., E. faecalis and E. faecium. From these studies, what is becoming evident is the role of the mobilome in adding new abilities to colonize new hosts and environments, and eventually in driving their evolution: specific clones associated with human infections or specific hosts can exist, but probably the consideration of these populations as strictly clonal groups is only partially correct. The variable presence of mobile genetic elements may, indeed, be one of the factors involved in the evolution of one specific group in a specific host and/or environment. Certainly more extensive studies using new high throughput technologies are mandatory to fully understand the evolution of predominant clones and species in different hosts and environments. Frontiers Research Foundation 2012-03-14 /pmc/articles/PMC3303144/ /pubmed/22435066 http://dx.doi.org/10.3389/fmicb.2012.00095 Text en Copyright © 2012 Santagati, Campanile and Stefani. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Microbiology Santagati, Maria Campanile, Floriana Stefani, Stefania Genomic Diversification of Enterococci in Hosts: The Role of the Mobilome |
title | Genomic Diversification of Enterococci in Hosts: The Role of the Mobilome |
title_full | Genomic Diversification of Enterococci in Hosts: The Role of the Mobilome |
title_fullStr | Genomic Diversification of Enterococci in Hosts: The Role of the Mobilome |
title_full_unstemmed | Genomic Diversification of Enterococci in Hosts: The Role of the Mobilome |
title_short | Genomic Diversification of Enterococci in Hosts: The Role of the Mobilome |
title_sort | genomic diversification of enterococci in hosts: the role of the mobilome |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303144/ https://www.ncbi.nlm.nih.gov/pubmed/22435066 http://dx.doi.org/10.3389/fmicb.2012.00095 |
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