Cargando…

The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer

In 1995, the steroid receptor coactivator-1 (SRC-1) was identified as the first authentic steroid receptor coactivator. Since then, the SRC proteins have remained at the epicenter of coregulator biology, molecular endocrinology and endocrine-related cancer. Cumulative works on SRC-1 have shown that...

Descripción completa

Detalles Bibliográficos
Autores principales: Walsh, Claire A., Qin, Li, Tien, Jean Ching-Yi, Young, Leonie S., Xu, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303173/
https://www.ncbi.nlm.nih.gov/pubmed/22419892
http://dx.doi.org/10.7150/ijbs.4125
_version_ 1782226728682258432
author Walsh, Claire A.
Qin, Li
Tien, Jean Ching-Yi
Young, Leonie S.
Xu, Jianming
author_facet Walsh, Claire A.
Qin, Li
Tien, Jean Ching-Yi
Young, Leonie S.
Xu, Jianming
author_sort Walsh, Claire A.
collection PubMed
description In 1995, the steroid receptor coactivator-1 (SRC-1) was identified as the first authentic steroid receptor coactivator. Since then, the SRC proteins have remained at the epicenter of coregulator biology, molecular endocrinology and endocrine-related cancer. Cumulative works on SRC-1 have shown that it is primarily a nuclear receptor coregulator and functions to construct highly specific enzymatic protein complexes which can execute efficient and successful transcriptional activation of designated target genes. The versatile nature of SRC-1 enables it to respond to steroid dependent and steroid independent stimulation, allowing it to bind across many families of transcription factors to orchestrate and regulate complex physiological reactions. This review highlights the multiple functions of SRC-1 in the development and maintenance of normal tissue functions as well as its major role in mediating hormone receptor responsiveness. Insights from genetically manipulated mouse models and clinical data suggest SRC-1 is significantly overexpressed in many cancers, in particular, cancers of the reproductive tissues. SRC-1 has been associated with cellular proliferation and tumor growth but its major tumorigenic contributions are promotion and execution of breast cancer metastasis and mediation of resistance to endocrine therapies. The ability of SRC-1 to coordinate multiple signaling pathways makes it an important player in tumor cells' escape of targeted therapy.
format Online
Article
Text
id pubmed-3303173
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-33031732012-03-14 The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer Walsh, Claire A. Qin, Li Tien, Jean Ching-Yi Young, Leonie S. Xu, Jianming Int J Biol Sci Review In 1995, the steroid receptor coactivator-1 (SRC-1) was identified as the first authentic steroid receptor coactivator. Since then, the SRC proteins have remained at the epicenter of coregulator biology, molecular endocrinology and endocrine-related cancer. Cumulative works on SRC-1 have shown that it is primarily a nuclear receptor coregulator and functions to construct highly specific enzymatic protein complexes which can execute efficient and successful transcriptional activation of designated target genes. The versatile nature of SRC-1 enables it to respond to steroid dependent and steroid independent stimulation, allowing it to bind across many families of transcription factors to orchestrate and regulate complex physiological reactions. This review highlights the multiple functions of SRC-1 in the development and maintenance of normal tissue functions as well as its major role in mediating hormone receptor responsiveness. Insights from genetically manipulated mouse models and clinical data suggest SRC-1 is significantly overexpressed in many cancers, in particular, cancers of the reproductive tissues. SRC-1 has been associated with cellular proliferation and tumor growth but its major tumorigenic contributions are promotion and execution of breast cancer metastasis and mediation of resistance to endocrine therapies. The ability of SRC-1 to coordinate multiple signaling pathways makes it an important player in tumor cells' escape of targeted therapy. Ivyspring International Publisher 2012-03-07 /pmc/articles/PMC3303173/ /pubmed/22419892 http://dx.doi.org/10.7150/ijbs.4125 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Walsh, Claire A.
Qin, Li
Tien, Jean Ching-Yi
Young, Leonie S.
Xu, Jianming
The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
title The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
title_full The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
title_fullStr The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
title_full_unstemmed The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
title_short The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
title_sort function of steroid receptor coactivator-1 in normal tissues and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303173/
https://www.ncbi.nlm.nih.gov/pubmed/22419892
http://dx.doi.org/10.7150/ijbs.4125
work_keys_str_mv AT walshclairea thefunctionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT qinli thefunctionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT tienjeanchingyi thefunctionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT youngleonies thefunctionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT xujianming thefunctionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT walshclairea functionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT qinli functionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT tienjeanchingyi functionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT youngleonies functionofsteroidreceptorcoactivator1innormaltissuesandcancer
AT xujianming functionofsteroidreceptorcoactivator1innormaltissuesandcancer