Cargando…

Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician's Request for a More Integrated Approach

Detalles Bibliográficos
Autores principales:	Allegaert, Karel, Smits, Anne, van den Anker, Johannes N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303567/ https://www.ncbi.nlm.nih.gov/pubmed/22500073 http://dx.doi.org/10.1155/2012/103763

Ejemplares similares

Individualized dosing of aminoglycosides in neonates: mission accomplished or work in progress?
por: van den Anker, John N., et al.
Publicado: (2009)

A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates
por: Smits, Anne, et al.
Publicado: (2020)

Effective analgesia after cesarean delivery needs pharmacokinetic input
por: Kulo, Aida, et al.
Publicado: (2012)

Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery
por: Mian, Paola, et al.
Publicado: (2021)

Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus
por: Mian, Paola, et al.
Publicado: (2020)

Creatinine Trends to Detect Ibuprofen-Related Maturational Adverse Drug Events in Neonatal Life: A Simulation Study for the ELBW Newborn
por: van Donge, Tamara, et al.
Publicado: (2021)

Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women
por: Mian, Paola, et al.
Publicado: (2019)

Dose‐Related Adverse Drug Events in Neonates: Recognition and Assessment
por: Allegaert, Karel, et al.
Publicado: (2021)

Challenges Related to Acquisition of Physiological Data for Physiologically Based Pharmacokinetic (PBPK) Models in Postpartum, Lactating Women and Breastfed Infants—A Contribution from the ConcePTION Project
por: Van Neste, Martje, et al.
Publicado: (2023)

Amikacin or Vancomycin Exposure Alters the Postnatal Serum Creatinine Dynamics in Extreme Low Birth Weight Neonates
por: van Donge, Tamara, et al.
Publicado: (2021)

Screening Laboratory Requests
por: Petti, Cathy A., et al.
Publicado: (2006)

Quantitative Prediction of Drug–Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is it Worth It?
por: Tod, M, et al.
Publicado: (2017)

Response to “Quantitative Prediction of Drug‐Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is It Worth?”
por: Templeton, IE, et al.
Publicado: (2017)

The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling
por: Allegaert, Karel, et al.
Publicado: (2022)

Missing emergency drugs in ICU - A clinician's nightmare!
por: Williams, Aparna, et al.
Publicado: (2011)

Pharmacokinetics of Antibiotics in Pediatric Intensive Care: Fostering Variability to Attain Precision Medicine
por: Gijsen, Matthias, et al.
Publicado: (2021)

Rational Use of Antibiotics in Neonates: Still in Search of Tailored Tools
por: van den Anker, John, et al.
Publicado: (2019)

Adverse drug events in pediatric intensive care are common, but improvement strategies exist and are effective
por: Allegaert, Karel
Publicado: (2016)

Comment on: "Preterm Physiologically Based Pharmacokinetic Model, Part I and Part II”
por: Völler, Swantje, et al.
Publicado: (2021)

The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics: A Paired Analysis
por: Kulo, Aida, et al.
Publicado: (2012)

Renal Precision Medicine in Neonates and Acute Kidney Injury: How to Convert a Cloud of Creatinine Observations to Support Clinical Decisions
por: Allegaert, Karel, et al.
Publicado: (2020)

To Bloc or Not to Bloc: Challenges in the Management of Patients Requesting “En-Bloc Capsulectomy”
por: Johal, Kavan S, et al.
Publicado: (2020)

Acute Maternal Fasting or Fluid Abstention Does Not Significantly Affect the Macronutrient Composition of Human Milk: Clinical and Clinical Research Relevance
por: Allegaert, Karel, et al.
Publicado: (2020)

Neonatal pain management: still in search of the Holy Grail
por: Allegaert, Karel, et al.
Publicado: (2016)

Prophylaxis of Ophthalmia Neonatorum: A Request for Statistics
por: Walker, A. Nimmo
Publicado: (1910)

Clinicians and Information Technology
por: Wood, J. D. D., et al.
Publicado: (1991)

The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development
por: Ayuso, Miriam, et al.
Publicado: (2020)

Perinatal Pharmacology
por: Allegaert, Karel, et al.
Publicado: (2014)

Pharmacokinetic Imaging with Radiolabeled Molecularly Targeted Anticancer Drugs
por: Bauer, Martin, et al.
Publicado: (2020)

More Vigilance on Generic Drugs are Necessary
por: John, Mathew
Publicado: (2020)

Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved
por: Allegaert, Karel
Publicado: (2016)

The Flynn Effect : An Alert to Clinicians
por: Sarkar, Jaydip
Publicado: (2004)

Cyclical vomiting and clinician's dilemma
por: Chatterjee, Seshadri Sekhar, et al.
Publicado: (2021)

Paracetamol pharmacokinetics and metabolism in young women
por: Allegaert, Karel, et al.
Publicado: (2015)

Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates
por: Samardzic, Janko, et al.
Publicado: (2016)

Characterizing dynamics of serum creatinine and creatinine clearance in extremely low birth weight neonates during the first 6 weeks of life
por: van Donge, Tamara, et al.
Publicado: (2020)

Clinician-to-clinician electronic consultation in cardiology is also a digital health technology for cardiovascular care
por: González-Juanatey, José R, et al.
Publicado: (2023)

Clinical pharmacokinetics of vancomycin in the neonate: a review
por: Pacifici, Gian Maria, et al.
Publicado: (2012)

Physiologically Based Pharmacokinetic Model for Prediction of Leflunomide and Teriflunomide: Should Consideration Be Given to Cannalicular Efflux Transporters?
por: Srinivas, NR
Publicado: (2015)

Research integrity — it’s about more than misconduct
por: Downey, Frances, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u19kaidghqu4vqnnpou1gf91iv