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Leptin in Anorexia and Cachexia Syndrome
Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass. It decreases food intake and increases energy expenditure by affecting the balance between orexigenic and anorexigenic hypothalamic pathways. Low leptin levels are responsible for the compensatory increase i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303568/ https://www.ncbi.nlm.nih.gov/pubmed/22518191 http://dx.doi.org/10.1155/2012/287457 |
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author | Engineer, Diana R. Garcia, Jose M. |
author_facet | Engineer, Diana R. Garcia, Jose M. |
author_sort | Engineer, Diana R. |
collection | PubMed |
description | Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass. It decreases food intake and increases energy expenditure by affecting the balance between orexigenic and anorexigenic hypothalamic pathways. Low leptin levels are responsible for the compensatory increase in appetite and body weight and decreased energy expenditure (EE) following caloric deprivation. The anorexia-cachexia syndrome is a complication of many chronic conditions including cancer, chronic obstructive pulmonary disease, congestive heart failure, chronic kidney disease, and aging, where the decrease in body weight and food intake is not followed by a compensatory increase in appetite or decreased EE. Crosstalk between leptin and inflammatory signaling known to be activated in these conditions may be responsible for this paradox. This manuscript will review the evidence and potential mechanisms mediating changes in the leptin pathway in the setting of anorexia and cachexia associated with chronic diseases. |
format | Online Article Text |
id | pubmed-3303568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33035682012-04-19 Leptin in Anorexia and Cachexia Syndrome Engineer, Diana R. Garcia, Jose M. Int J Pept Review Article Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass. It decreases food intake and increases energy expenditure by affecting the balance between orexigenic and anorexigenic hypothalamic pathways. Low leptin levels are responsible for the compensatory increase in appetite and body weight and decreased energy expenditure (EE) following caloric deprivation. The anorexia-cachexia syndrome is a complication of many chronic conditions including cancer, chronic obstructive pulmonary disease, congestive heart failure, chronic kidney disease, and aging, where the decrease in body weight and food intake is not followed by a compensatory increase in appetite or decreased EE. Crosstalk between leptin and inflammatory signaling known to be activated in these conditions may be responsible for this paradox. This manuscript will review the evidence and potential mechanisms mediating changes in the leptin pathway in the setting of anorexia and cachexia associated with chronic diseases. Hindawi Publishing Corporation 2012 2012-02-08 /pmc/articles/PMC3303568/ /pubmed/22518191 http://dx.doi.org/10.1155/2012/287457 Text en Copyright © 2012 D. R. Engineer and J. M. Garcia. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Engineer, Diana R. Garcia, Jose M. Leptin in Anorexia and Cachexia Syndrome |
title | Leptin in Anorexia and Cachexia Syndrome |
title_full | Leptin in Anorexia and Cachexia Syndrome |
title_fullStr | Leptin in Anorexia and Cachexia Syndrome |
title_full_unstemmed | Leptin in Anorexia and Cachexia Syndrome |
title_short | Leptin in Anorexia and Cachexia Syndrome |
title_sort | leptin in anorexia and cachexia syndrome |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303568/ https://www.ncbi.nlm.nih.gov/pubmed/22518191 http://dx.doi.org/10.1155/2012/287457 |
work_keys_str_mv | AT engineerdianar leptininanorexiaandcachexiasyndrome AT garciajosem leptininanorexiaandcachexiasyndrome |