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Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals

Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid dis...

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Autores principales: Marcus, Robin L., Addison, Odessa, Dibble, Leland E., Foreman, K. Bo, Morrell, Glen, LaStayo, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303569/
https://www.ncbi.nlm.nih.gov/pubmed/22500231
http://dx.doi.org/10.1155/2012/629637
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author Marcus, Robin L.
Addison, Odessa
Dibble, Leland E.
Foreman, K. Bo
Morrell, Glen
LaStayo, Paul
author_facet Marcus, Robin L.
Addison, Odessa
Dibble, Leland E.
Foreman, K. Bo
Morrell, Glen
LaStayo, Paul
author_sort Marcus, Robin L.
collection PubMed
description Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regression models. Results. The predictors as a group contributed 27–45% of the variance in all outcome measures; however, IMAT contributed between 8–15% of the variance in all four mobility variables, while lean explained only 5% variance in only one mobility measure. Conclusions. Thigh IMAT, a newly identified muscle impairment appears to be a potent muscle variable related to the ability of older adults to move about in their community.
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spelling pubmed-33035692012-04-12 Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals Marcus, Robin L. Addison, Odessa Dibble, Leland E. Foreman, K. Bo Morrell, Glen LaStayo, Paul J Aging Res Clinical Study Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regression models. Results. The predictors as a group contributed 27–45% of the variance in all outcome measures; however, IMAT contributed between 8–15% of the variance in all four mobility variables, while lean explained only 5% variance in only one mobility measure. Conclusions. Thigh IMAT, a newly identified muscle impairment appears to be a potent muscle variable related to the ability of older adults to move about in their community. Hindawi Publishing Corporation 2012 2012-02-06 /pmc/articles/PMC3303569/ /pubmed/22500231 http://dx.doi.org/10.1155/2012/629637 Text en Copyright © 2012 Robin L. Marcus et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Marcus, Robin L.
Addison, Odessa
Dibble, Leland E.
Foreman, K. Bo
Morrell, Glen
LaStayo, Paul
Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals
title Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals
title_full Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals
title_fullStr Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals
title_full_unstemmed Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals
title_short Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals
title_sort intramuscular adipose tissue, sarcopenia, and mobility function in older individuals
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303569/
https://www.ncbi.nlm.nih.gov/pubmed/22500231
http://dx.doi.org/10.1155/2012/629637
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