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Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals
Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid dis...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303569/ https://www.ncbi.nlm.nih.gov/pubmed/22500231 http://dx.doi.org/10.1155/2012/629637 |
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author | Marcus, Robin L. Addison, Odessa Dibble, Leland E. Foreman, K. Bo Morrell, Glen LaStayo, Paul |
author_facet | Marcus, Robin L. Addison, Odessa Dibble, Leland E. Foreman, K. Bo Morrell, Glen LaStayo, Paul |
author_sort | Marcus, Robin L. |
collection | PubMed |
description | Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regression models. Results. The predictors as a group contributed 27–45% of the variance in all outcome measures; however, IMAT contributed between 8–15% of the variance in all four mobility variables, while lean explained only 5% variance in only one mobility measure. Conclusions. Thigh IMAT, a newly identified muscle impairment appears to be a potent muscle variable related to the ability of older adults to move about in their community. |
format | Online Article Text |
id | pubmed-3303569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33035692012-04-12 Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals Marcus, Robin L. Addison, Odessa Dibble, Leland E. Foreman, K. Bo Morrell, Glen LaStayo, Paul J Aging Res Clinical Study Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method. 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regression models. Results. The predictors as a group contributed 27–45% of the variance in all outcome measures; however, IMAT contributed between 8–15% of the variance in all four mobility variables, while lean explained only 5% variance in only one mobility measure. Conclusions. Thigh IMAT, a newly identified muscle impairment appears to be a potent muscle variable related to the ability of older adults to move about in their community. Hindawi Publishing Corporation 2012 2012-02-06 /pmc/articles/PMC3303569/ /pubmed/22500231 http://dx.doi.org/10.1155/2012/629637 Text en Copyright © 2012 Robin L. Marcus et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Marcus, Robin L. Addison, Odessa Dibble, Leland E. Foreman, K. Bo Morrell, Glen LaStayo, Paul Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
title | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
title_full | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
title_fullStr | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
title_full_unstemmed | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
title_short | Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals |
title_sort | intramuscular adipose tissue, sarcopenia, and mobility function in older individuals |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303569/ https://www.ncbi.nlm.nih.gov/pubmed/22500231 http://dx.doi.org/10.1155/2012/629637 |
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