Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate

Helminth parasites induce Th2 immune responses. Immunological mechanisms leading to Th2 induction are mainly dependent on IL-4. However, early source of IL-4 has not been precisely identified. Noticeably, basophils seem to be important mediators for inducing and maintaining the Th2 response probably...

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Detalles Bibliográficos
Autores principales: Leon-Cabrera, Sonia, Flisser, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303586/
https://www.ncbi.nlm.nih.gov/pubmed/22500083
http://dx.doi.org/10.1155/2012/274150
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author Leon-Cabrera, Sonia
Flisser, Ana
author_facet Leon-Cabrera, Sonia
Flisser, Ana
author_sort Leon-Cabrera, Sonia
collection PubMed
description Helminth parasites induce Th2 immune responses. Immunological mechanisms leading to Th2 induction are mainly dependent on IL-4. However, early source of IL-4 has not been precisely identified. Noticeably, basophils seem to be important mediators for inducing and maintaining the Th2 response probably because they secrete IL-4 and exert functions similar to APCs. Nevertheless, recent experimental evidence points that DCs could be also significant participants during this process. The involvement of basophils during memory responses is also discussed.
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spelling pubmed-33035862012-04-12 Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate Leon-Cabrera, Sonia Flisser, Ana J Biomed Biotechnol Review Article Helminth parasites induce Th2 immune responses. Immunological mechanisms leading to Th2 induction are mainly dependent on IL-4. However, early source of IL-4 has not been precisely identified. Noticeably, basophils seem to be important mediators for inducing and maintaining the Th2 response probably because they secrete IL-4 and exert functions similar to APCs. Nevertheless, recent experimental evidence points that DCs could be also significant participants during this process. The involvement of basophils during memory responses is also discussed. Hindawi Publishing Corporation 2012 2012-02-20 /pmc/articles/PMC3303586/ /pubmed/22500083 http://dx.doi.org/10.1155/2012/274150 Text en Copyright © 2012 S. Leon-Cabrera and A. Flisser. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Leon-Cabrera, Sonia
Flisser, Ana
Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate
title Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate
title_full Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate
title_fullStr Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate
title_full_unstemmed Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate
title_short Are Basophils Important Mediators for Helminth-Induced Th2 Immune Responses? A Debate
title_sort are basophils important mediators for helminth-induced th2 immune responses? a debate
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303586/
https://www.ncbi.nlm.nih.gov/pubmed/22500083
http://dx.doi.org/10.1155/2012/274150
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