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Insulin in Central Nervous System: More than Just a Peripheral Hormone
Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may const...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303591/ https://www.ncbi.nlm.nih.gov/pubmed/22500228 http://dx.doi.org/10.1155/2012/384017 |
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author | Duarte, Ana I. Moreira, Paula I. Oliveira, Catarina R. |
author_facet | Duarte, Ana I. Moreira, Paula I. Oliveira, Catarina R. |
author_sort | Duarte, Ana I. |
collection | PubMed |
description | Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the “brain-type diabetes.” In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective. And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human “healthy” longevity. Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach. |
format | Online Article Text |
id | pubmed-3303591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33035912012-04-12 Insulin in Central Nervous System: More than Just a Peripheral Hormone Duarte, Ana I. Moreira, Paula I. Oliveira, Catarina R. J Aging Res Review Article Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the “brain-type diabetes.” In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective. And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human “healthy” longevity. Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach. Hindawi Publishing Corporation 2012 2012-02-21 /pmc/articles/PMC3303591/ /pubmed/22500228 http://dx.doi.org/10.1155/2012/384017 Text en Copyright © 2012 Ana I. Duarte et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Duarte, Ana I. Moreira, Paula I. Oliveira, Catarina R. Insulin in Central Nervous System: More than Just a Peripheral Hormone |
title | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
title_full | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
title_fullStr | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
title_full_unstemmed | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
title_short | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
title_sort | insulin in central nervous system: more than just a peripheral hormone |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303591/ https://www.ncbi.nlm.nih.gov/pubmed/22500228 http://dx.doi.org/10.1155/2012/384017 |
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