Cargando…

Insulin in Central Nervous System: More than Just a Peripheral Hormone

Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may const...

Descripción completa

Detalles Bibliográficos
Autores principales: Duarte, Ana I., Moreira, Paula I., Oliveira, Catarina R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303591/
https://www.ncbi.nlm.nih.gov/pubmed/22500228
http://dx.doi.org/10.1155/2012/384017
_version_ 1782226761324429312
author Duarte, Ana I.
Moreira, Paula I.
Oliveira, Catarina R.
author_facet Duarte, Ana I.
Moreira, Paula I.
Oliveira, Catarina R.
author_sort Duarte, Ana I.
collection PubMed
description Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the “brain-type diabetes.” In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective. And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human “healthy” longevity. Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach.
format Online
Article
Text
id pubmed-3303591
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33035912012-04-12 Insulin in Central Nervous System: More than Just a Peripheral Hormone Duarte, Ana I. Moreira, Paula I. Oliveira, Catarina R. J Aging Res Review Article Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the “brain-type diabetes.” In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective. And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human “healthy” longevity. Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach. Hindawi Publishing Corporation 2012 2012-02-21 /pmc/articles/PMC3303591/ /pubmed/22500228 http://dx.doi.org/10.1155/2012/384017 Text en Copyright © 2012 Ana I. Duarte et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Duarte, Ana I.
Moreira, Paula I.
Oliveira, Catarina R.
Insulin in Central Nervous System: More than Just a Peripheral Hormone
title Insulin in Central Nervous System: More than Just a Peripheral Hormone
title_full Insulin in Central Nervous System: More than Just a Peripheral Hormone
title_fullStr Insulin in Central Nervous System: More than Just a Peripheral Hormone
title_full_unstemmed Insulin in Central Nervous System: More than Just a Peripheral Hormone
title_short Insulin in Central Nervous System: More than Just a Peripheral Hormone
title_sort insulin in central nervous system: more than just a peripheral hormone
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303591/
https://www.ncbi.nlm.nih.gov/pubmed/22500228
http://dx.doi.org/10.1155/2012/384017
work_keys_str_mv AT duarteanai insulinincentralnervoussystemmorethanjustaperipheralhormone
AT moreirapaulai insulinincentralnervoussystemmorethanjustaperipheralhormone
AT oliveiracatarinar insulinincentralnervoussystemmorethanjustaperipheralhormone