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Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE

SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert diffe...

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Detalles Bibliográficos
Autores principales: Su, Ding-Lei, Lu, Zhi-Min, Shen, Min-Ning, Li, Xia, Sun, Ling-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303597/
https://www.ncbi.nlm.nih.gov/pubmed/22500087
http://dx.doi.org/10.1155/2012/347141
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author Su, Ding-Lei
Lu, Zhi-Min
Shen, Min-Ning
Li, Xia
Sun, Ling-Yun
author_facet Su, Ding-Lei
Lu, Zhi-Min
Shen, Min-Ning
Li, Xia
Sun, Ling-Yun
author_sort Su, Ding-Lei
collection PubMed
description SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy.
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spelling pubmed-33035972012-04-12 Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE Su, Ding-Lei Lu, Zhi-Min Shen, Min-Ning Li, Xia Sun, Ling-Yun J Biomed Biotechnol Review Article SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy. Hindawi Publishing Corporation 2012 2012-02-15 /pmc/articles/PMC3303597/ /pubmed/22500087 http://dx.doi.org/10.1155/2012/347141 Text en Copyright © 2012 Ding-Lei Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Su, Ding-Lei
Lu, Zhi-Min
Shen, Min-Ning
Li, Xia
Sun, Ling-Yun
Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE
title Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE
title_full Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE
title_fullStr Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE
title_full_unstemmed Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE
title_short Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE
title_sort roles of pro- and anti-inflammatory cytokines in the pathogenesis of sle
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303597/
https://www.ncbi.nlm.nih.gov/pubmed/22500087
http://dx.doi.org/10.1155/2012/347141
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