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Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE
SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert diffe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303597/ https://www.ncbi.nlm.nih.gov/pubmed/22500087 http://dx.doi.org/10.1155/2012/347141 |
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author | Su, Ding-Lei Lu, Zhi-Min Shen, Min-Ning Li, Xia Sun, Ling-Yun |
author_facet | Su, Ding-Lei Lu, Zhi-Min Shen, Min-Ning Li, Xia Sun, Ling-Yun |
author_sort | Su, Ding-Lei |
collection | PubMed |
description | SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy. |
format | Online Article Text |
id | pubmed-3303597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33035972012-04-12 Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE Su, Ding-Lei Lu, Zhi-Min Shen, Min-Ning Li, Xia Sun, Ling-Yun J Biomed Biotechnol Review Article SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy. Hindawi Publishing Corporation 2012 2012-02-15 /pmc/articles/PMC3303597/ /pubmed/22500087 http://dx.doi.org/10.1155/2012/347141 Text en Copyright © 2012 Ding-Lei Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Su, Ding-Lei Lu, Zhi-Min Shen, Min-Ning Li, Xia Sun, Ling-Yun Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE |
title | Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE |
title_full | Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE |
title_fullStr | Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE |
title_full_unstemmed | Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE |
title_short | Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE |
title_sort | roles of pro- and anti-inflammatory cytokines in the pathogenesis of sle |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303597/ https://www.ncbi.nlm.nih.gov/pubmed/22500087 http://dx.doi.org/10.1155/2012/347141 |
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