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Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent pa...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303613/ https://www.ncbi.nlm.nih.gov/pubmed/22500174 http://dx.doi.org/10.1155/2012/594681 |
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author | Tulalamba, Warut Janvilisri, Tavan |
author_facet | Tulalamba, Warut Janvilisri, Tavan |
author_sort | Tulalamba, Warut |
collection | PubMed |
description | Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis. |
format | Online Article Text |
id | pubmed-3303613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33036132012-04-12 Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers Tulalamba, Warut Janvilisri, Tavan Int J Cell Biol Review Article Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis. Hindawi Publishing Corporation 2012 2012-03-05 /pmc/articles/PMC3303613/ /pubmed/22500174 http://dx.doi.org/10.1155/2012/594681 Text en Copyright © 2012 W. Tulalamba and T. Janvilisri. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tulalamba, Warut Janvilisri, Tavan Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
title | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
title_full | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
title_fullStr | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
title_full_unstemmed | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
title_short | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
title_sort | nasopharyngeal carcinoma signaling pathway: an update on molecular biomarkers |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303613/ https://www.ncbi.nlm.nih.gov/pubmed/22500174 http://dx.doi.org/10.1155/2012/594681 |
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