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Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers

Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent pa...

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Detalles Bibliográficos
Autores principales: Tulalamba, Warut, Janvilisri, Tavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303613/
https://www.ncbi.nlm.nih.gov/pubmed/22500174
http://dx.doi.org/10.1155/2012/594681
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author Tulalamba, Warut
Janvilisri, Tavan
author_facet Tulalamba, Warut
Janvilisri, Tavan
author_sort Tulalamba, Warut
collection PubMed
description Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis.
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spelling pubmed-33036132012-04-12 Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers Tulalamba, Warut Janvilisri, Tavan Int J Cell Biol Review Article Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis. Hindawi Publishing Corporation 2012 2012-03-05 /pmc/articles/PMC3303613/ /pubmed/22500174 http://dx.doi.org/10.1155/2012/594681 Text en Copyright © 2012 W. Tulalamba and T. Janvilisri. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tulalamba, Warut
Janvilisri, Tavan
Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
title Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
title_full Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
title_fullStr Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
title_full_unstemmed Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
title_short Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
title_sort nasopharyngeal carcinoma signaling pathway: an update on molecular biomarkers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303613/
https://www.ncbi.nlm.nih.gov/pubmed/22500174
http://dx.doi.org/10.1155/2012/594681
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