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Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?

Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition...

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Detalles Bibliográficos
Autores principales: Siniscalco, Dario, Sapone, Anna, Cirillo, Alessandra, Giordano, Catia, Maione, Sabatino, Antonucci, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303614/
https://www.ncbi.nlm.nih.gov/pubmed/22496609
http://dx.doi.org/10.1155/2012/480289
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author Siniscalco, Dario
Sapone, Anna
Cirillo, Alessandra
Giordano, Catia
Maione, Sabatino
Antonucci, Nicola
author_facet Siniscalco, Dario
Sapone, Anna
Cirillo, Alessandra
Giordano, Catia
Maione, Sabatino
Antonucci, Nicola
author_sort Siniscalco, Dario
collection PubMed
description Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition to repetitive and stereotypic verbal and nonverbal behaviours. Immune dysfunction has been confirmed with autistic children. There are no defined mechanisms of pathogenesis or curative therapy presently available. Indeed, ASDs are still untreatable. Available treatments for autism can be divided into behavioural, nutritional, and medical approaches, although no defined standard approach exists. Nowadays, stem cell therapy represents the great promise for the future of molecular medicine. Among the stem cell population, mesenchymal stem cells (MSCs) show probably best potential good results in medical research. Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease.
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spelling pubmed-33036142012-04-11 Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future? Siniscalco, Dario Sapone, Anna Cirillo, Alessandra Giordano, Catia Maione, Sabatino Antonucci, Nicola J Biomed Biotechnol Review Article Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition to repetitive and stereotypic verbal and nonverbal behaviours. Immune dysfunction has been confirmed with autistic children. There are no defined mechanisms of pathogenesis or curative therapy presently available. Indeed, ASDs are still untreatable. Available treatments for autism can be divided into behavioural, nutritional, and medical approaches, although no defined standard approach exists. Nowadays, stem cell therapy represents the great promise for the future of molecular medicine. Among the stem cell population, mesenchymal stem cells (MSCs) show probably best potential good results in medical research. Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease. Hindawi Publishing Corporation 2012 2012-02-13 /pmc/articles/PMC3303614/ /pubmed/22496609 http://dx.doi.org/10.1155/2012/480289 Text en Copyright © 2012 Dario Siniscalco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Siniscalco, Dario
Sapone, Anna
Cirillo, Alessandra
Giordano, Catia
Maione, Sabatino
Antonucci, Nicola
Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?
title Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?
title_full Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?
title_fullStr Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?
title_full_unstemmed Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?
title_short Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?
title_sort autism spectrum disorders: is mesenchymal stem cell personalized therapy the future?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303614/
https://www.ncbi.nlm.nih.gov/pubmed/22496609
http://dx.doi.org/10.1155/2012/480289
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