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Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?
Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303614/ https://www.ncbi.nlm.nih.gov/pubmed/22496609 http://dx.doi.org/10.1155/2012/480289 |
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author | Siniscalco, Dario Sapone, Anna Cirillo, Alessandra Giordano, Catia Maione, Sabatino Antonucci, Nicola |
author_facet | Siniscalco, Dario Sapone, Anna Cirillo, Alessandra Giordano, Catia Maione, Sabatino Antonucci, Nicola |
author_sort | Siniscalco, Dario |
collection | PubMed |
description | Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition to repetitive and stereotypic verbal and nonverbal behaviours. Immune dysfunction has been confirmed with autistic children. There are no defined mechanisms of pathogenesis or curative therapy presently available. Indeed, ASDs are still untreatable. Available treatments for autism can be divided into behavioural, nutritional, and medical approaches, although no defined standard approach exists. Nowadays, stem cell therapy represents the great promise for the future of molecular medicine. Among the stem cell population, mesenchymal stem cells (MSCs) show probably best potential good results in medical research. Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease. |
format | Online Article Text |
id | pubmed-3303614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33036142012-04-11 Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future? Siniscalco, Dario Sapone, Anna Cirillo, Alessandra Giordano, Catia Maione, Sabatino Antonucci, Nicola J Biomed Biotechnol Review Article Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition to repetitive and stereotypic verbal and nonverbal behaviours. Immune dysfunction has been confirmed with autistic children. There are no defined mechanisms of pathogenesis or curative therapy presently available. Indeed, ASDs are still untreatable. Available treatments for autism can be divided into behavioural, nutritional, and medical approaches, although no defined standard approach exists. Nowadays, stem cell therapy represents the great promise for the future of molecular medicine. Among the stem cell population, mesenchymal stem cells (MSCs) show probably best potential good results in medical research. Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease. Hindawi Publishing Corporation 2012 2012-02-13 /pmc/articles/PMC3303614/ /pubmed/22496609 http://dx.doi.org/10.1155/2012/480289 Text en Copyright © 2012 Dario Siniscalco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Siniscalco, Dario Sapone, Anna Cirillo, Alessandra Giordano, Catia Maione, Sabatino Antonucci, Nicola Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future? |
title | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future? |
title_full | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future? |
title_fullStr | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future? |
title_full_unstemmed | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future? |
title_short | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future? |
title_sort | autism spectrum disorders: is mesenchymal stem cell personalized therapy the future? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303614/ https://www.ncbi.nlm.nih.gov/pubmed/22496609 http://dx.doi.org/10.1155/2012/480289 |
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