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Micromechanical Thermal Assays of Ca(2+)-Regulated Thin-Filament Function and Modulation by Hypertrophic Cardiomyopathy Mutants of Human Cardiac Troponin

Microfabricated thermoelectric controllers can be employed to investigate mechanisms underlying myosin-driven sliding of Ca(2+)-regulated actin and disease-associated mutations in myofilament proteins. Specifically, we examined actin filament sliding—with or without human cardiac troponin (Tn) and α...

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Detalles Bibliográficos
Autores principales:	Brunet, Nicolas M., Mihajlović, Goran, Aledealat, Khaled, Wang, Fang, Xiong, Peng, von Molnár, Stephan, Chase, P. Bryant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303698/ https://www.ncbi.nlm.nih.gov/pubmed/22500102 http://dx.doi.org/10.1155/2012/657523

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