Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone

We report a case of torsade de pointes after intravenous amiodarone and concurrent hypokalemia. Despite treatment cessation and correction of electrolyte abnormalities, excessive QTc prolongation was noted, which persisted for 14 days. This prolonged course for QTc normalization may be attributed to...

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Autores principales: Kotsia, Anna P., Dimitriadis, Georgios, Baltogiannis, Giannis G., Kolettis, Theofilos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303706/
https://www.ncbi.nlm.nih.gov/pubmed/22474460
http://dx.doi.org/10.1155/2012/673019
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author Kotsia, Anna P.
Dimitriadis, Georgios
Baltogiannis, Giannis G.
Kolettis, Theofilos M.
author_facet Kotsia, Anna P.
Dimitriadis, Georgios
Baltogiannis, Giannis G.
Kolettis, Theofilos M.
author_sort Kotsia, Anna P.
collection PubMed
description We report a case of torsade de pointes after intravenous amiodarone and concurrent hypokalemia. Despite treatment cessation and correction of electrolyte abnormalities, excessive QTc prolongation was noted, which persisted for 14 days. This prolonged course for QTc normalization may be attributed to the high rate of amiodarone loading and concurrent electrolyte disturbances coupled with possible underlying individual variability in pharmacokinetics.
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spelling pubmed-33037062012-04-03 Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone Kotsia, Anna P. Dimitriadis, Georgios Baltogiannis, Giannis G. Kolettis, Theofilos M. Case Rep Med Case Report We report a case of torsade de pointes after intravenous amiodarone and concurrent hypokalemia. Despite treatment cessation and correction of electrolyte abnormalities, excessive QTc prolongation was noted, which persisted for 14 days. This prolonged course for QTc normalization may be attributed to the high rate of amiodarone loading and concurrent electrolyte disturbances coupled with possible underlying individual variability in pharmacokinetics. Hindawi Publishing Corporation 2012 2012-03-05 /pmc/articles/PMC3303706/ /pubmed/22474460 http://dx.doi.org/10.1155/2012/673019 Text en Copyright © 2012 Anna P. Kotsia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kotsia, Anna P.
Dimitriadis, Georgios
Baltogiannis, Giannis G.
Kolettis, Theofilos M.
Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone
title Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone
title_full Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone
title_fullStr Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone
title_full_unstemmed Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone
title_short Torsade de Pointes and Persistent QTc Prolongation after Intravenous Amiodarone
title_sort torsade de pointes and persistent qtc prolongation after intravenous amiodarone
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303706/
https://www.ncbi.nlm.nih.gov/pubmed/22474460
http://dx.doi.org/10.1155/2012/673019
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