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Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer
Aim. To investigate the involvement of Dickkopf-1 expression in gastric cancer. Methods. Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjace...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303707/ https://www.ncbi.nlm.nih.gov/pubmed/22496615 http://dx.doi.org/10.1155/2012/804592 |
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author | Gao, Chengcheng Xie, Rui Ren, Chengcheng Yang, Xiaozhong |
author_facet | Gao, Chengcheng Xie, Rui Ren, Chengcheng Yang, Xiaozhong |
author_sort | Gao, Chengcheng |
collection | PubMed |
description | Aim. To investigate the involvement of Dickkopf-1 expression in gastric cancer. Methods. Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjacent noncancerous tissues in gastric cancer patients. Results. Dickkopf-1 mRNA and protein expression levels were both significantly upregulated in gastric cancer lesions compared with adjacent noncancerous tissues. Its positive expression was correlated with depth of invasion, vessel invasion, lymph node and distant metastasis, and TNM stage of tumors. Additionally, in stages I, II, and III gastric cancers, the 5- year survival rate of patients with a high expression of Dickkopf-1 was significantly lower than that in patients with low expression. In stage IV, Dickkopf-1 expression did not correlate with the 5-year survival rate. Further multivariate analysis suggested that the up-regulation of Dickkopf-1 was an independent prognostic indicator for gastric cancer. Conclusion. A subset of cases with gastric cancer revealed the up-regulation of Dickkopf-1, which was associated with a progressive pathological feature and an aggressive clinical course. Therefore, Dickkopf-1 expression may be predictor for poor prognosis in patients with gastric cancer. This is the first report describing the involvement of Dickkopf-1 in gastric cancer. |
format | Online Article Text |
id | pubmed-3303707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33037072012-04-11 Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer Gao, Chengcheng Xie, Rui Ren, Chengcheng Yang, Xiaozhong J Biomed Biotechnol Clinical Study Aim. To investigate the involvement of Dickkopf-1 expression in gastric cancer. Methods. Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjacent noncancerous tissues in gastric cancer patients. Results. Dickkopf-1 mRNA and protein expression levels were both significantly upregulated in gastric cancer lesions compared with adjacent noncancerous tissues. Its positive expression was correlated with depth of invasion, vessel invasion, lymph node and distant metastasis, and TNM stage of tumors. Additionally, in stages I, II, and III gastric cancers, the 5- year survival rate of patients with a high expression of Dickkopf-1 was significantly lower than that in patients with low expression. In stage IV, Dickkopf-1 expression did not correlate with the 5-year survival rate. Further multivariate analysis suggested that the up-regulation of Dickkopf-1 was an independent prognostic indicator for gastric cancer. Conclusion. A subset of cases with gastric cancer revealed the up-regulation of Dickkopf-1, which was associated with a progressive pathological feature and an aggressive clinical course. Therefore, Dickkopf-1 expression may be predictor for poor prognosis in patients with gastric cancer. This is the first report describing the involvement of Dickkopf-1 in gastric cancer. Hindawi Publishing Corporation 2012 2012-03-04 /pmc/articles/PMC3303707/ /pubmed/22496615 http://dx.doi.org/10.1155/2012/804592 Text en Copyright © 2012 Chengcheng Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Gao, Chengcheng Xie, Rui Ren, Chengcheng Yang, Xiaozhong Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer |
title | Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer |
title_full | Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer |
title_fullStr | Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer |
title_full_unstemmed | Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer |
title_short | Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer |
title_sort | dickkopf-1 expression is a novel prognostic marker for gastric cancer |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303707/ https://www.ncbi.nlm.nih.gov/pubmed/22496615 http://dx.doi.org/10.1155/2012/804592 |
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