Adaptive Immune Response to Model Antigens Is Impaired in Murine Leukocyte-Adhesion Deficiency-1 Revealing Elevated Activation Thresholds In Vivo

Absence of β (2) integrins (CD11/CD18) leads to leukocyte-adhesion deficiency-1 (LAD1), a rare primary immunodeficiency syndrome. Although extensive in vitro work has established an essential function of β (2) integrins in adhesive and signaling properties for cells of the innate and adaptive immune...

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Detalles Bibliográficos
Autores principales: Peters, Thorsten, Bloch, Wilhelm, Pabst, Oliver, Wickenhauser, Claudia, Uthoff-Hachenberg, Claudia, Schmidt, Susanne V., Varga, Georg, Grabbe, Stephan, Kess, Daniel, Oreshkova, Tsvetelina, Sindrilaru, Anca, Addicks, Klaus, Förster, Reinhold, Müller, Werner, Scharffetter-Kochanek, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303708/
https://www.ncbi.nlm.nih.gov/pubmed/22474478
http://dx.doi.org/10.1155/2012/450738

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