Inflammation-Associated Nitrotyrosination Affects TCR Recognition through Reduced Stability and Alteration of the Molecular Surface of the MHC Complex

Nitrotyrosination of proteins, a hallmark of inflammation, may result in the production of MHC-restricted neoantigens that can be recognized by T cells and bypass the constraints of immunological self-tolerance. Here we biochemically and structurally assessed how nitrotyrosination of the lymphocytic...

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Detalles Bibliográficos
Autores principales: Madhurantakam, Chaithanya, Duru, Adil D., Sandalova, Tatyana, Webb, John R., Achour, Adnane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303804/
https://www.ncbi.nlm.nih.gov/pubmed/22431983
http://dx.doi.org/10.1371/journal.pone.0032805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303804/
https://www.ncbi.nlm.nih.gov/pubmed/22431983
http://dx.doi.org/10.1371/journal.pone.0032805

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