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Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

OBJECTIVE: Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartilage metabolism. METHODS: OA was induced...

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Detalles Bibliográficos
Autores principales:	Funck-Brentano, Thomas, Lin, Hilène, Hay, Eric, Ah Kioon, Marie-Dominique, Schiltz, Corinne, Hannouche, Didier, Nizard, Rémy, Lioté, Frédéric, Orcel, Philippe, de Vernejoul, Marie-Christine, Cohen-Solal, Martine Esther
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303845/ https://www.ncbi.nlm.nih.gov/pubmed/22432033 http://dx.doi.org/10.1371/journal.pone.0033543

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